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目的了解成年居民血清Ghrelin水平与体成分及脂代谢相关细胞因子的关系。方法选取辽宁、河南和湖南三省591名60岁以下城乡成年居民作为研究对象,测量身高、体重、腰围、臀围、体脂百分比,计算体质指数、腰臀比,测定血清总胆固醇、甘油三酯、低密度脂蛋白胆固醇、高密度脂蛋白胆固醇、Ghrelin、瘦素、血清钙及载脂蛋白A1/载脂蛋白B。结果成年男性居民Ghrelin浓度为24.12μg/L,女性为23.62μg/L,差异无统计学意义。随血清Ghrelin水平的升高,腰围、体质指数、腰臀比、超重/肥胖率、中心性肥胖率、体脂百分比、总胆固醇、甘油三酯、低密度脂蛋白胆固醇及血清瘦素水平逐渐降低(P<0.05),血清高密度脂蛋白胆固醇及载脂蛋白A1/载脂蛋白B呈现逐渐增高的趋势(P<0.05),臀围和血清钙水平变化趋势不明显。相关分析结果显示,Ghrelin浓度与BMI、腰围、腰臀比、体脂百分比、总胆固醇、低密度脂蛋白胆固醇以及瘦素明显相关(P<0.05)。结论 Ghrelin水平与体成分及脂代谢相关细胞因子有关联,但与瘦素和体脂百分比的相关更为密切。
Abstract：Objective To describe the relationships between serum Ghrelin and body composition and lipid metabolism-related cytokines among Chinese adults. Methods A total of 591 adults younger than 60 years were selected from urban and rural areas of Liaoning,Henan and Hunan Provinces. Height,body weight,waist circumference,hip circumference,body mass index( BMI),waist-hip ratio( WHR),body fat percentage( % BF),blood lipid,serum leptin,Ghrelin and Ca were measured in all samples.Results The mean serum Ghrelin concentration in males was 24. 12 μg / L and in females23. 62 μg / L. There were no significant differences between different genders. With the increasing concentration in serum Ghrelin,a significant decreasing trend( P < 0. 05) was found in waist circumference,BMI,WHR,overweight / obesity rates,central obesity rates,BF%,TC,TG,LDL-C and serum leptin. A significant increasing trend( P <0. 05) was found in HDL-C and Apo A1 / Apo B, and no significant change in hipcircumference and serum Ca were found. Correlations showed that there was a significant correlation among serum Ghrelin,BMI,waist circumference,WHR,BF%,TC,LDL-C and leptin( P < 0. 05). Conclusions Serum Ghrelin level correlates strongly with body composition and lipid metabolism-related cytokines, and can have a more closely associations with BF% and leptin.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2015.06.005
中图分类号:R151
引用信息:
[1]苏畅,杜文雯,王惠君,等.辽宁、河南和湖南省591名成年居民血清Ghrelin水平与体成分及脂代谢相关细胞因子关系的分析[J].卫生研究,2015,44(06):904-907+927.DOI:10.19813/j.cnki.weishengyanjiu.2015.06.005.
基金信息:
国家自然科学基金(No.81172666); 中国疾病预防控制中心青年基金(No.2013B103)
2015-11-30
2015-11-30