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目的 探究健康母乳低聚糖(human milk oligosaccharides, HMOs)水平与6月龄内婴儿体格生长的关系。方法 基于一项关于母乳成分的全国多阶段分层抽样大型横断面调查，于2011—2013年选择195名产后6个月内的哺乳期妇女及其婴儿作为研究对象。通过超高效液相色谱串联质谱法测定母乳中HMOs的含量，并对婴儿进行体格检查，收集其身高、体重和头围数据，计算Z评分，通过一般线性模型分析HMOs含量与婴儿生长发育之间的关系。结果 成熟乳总HMOs及总唾液酸化HMOs与身长别体重(weight for length Z-score, WLZ)、年龄别体重(weight for age Z-score, WAZ)和年龄别体质指数(BMI for age Z-score, BAZ)呈负相关(β=-0.80～-0.25,P<0.05),6′-唾液酸乳糖(6′-sialyllactosamine, 6′-SL)、乳糖N-唾液酸四糖c(sialyllacto-N-tetraose c, LSTc)、二唾液酸乳糖新四糖(nisialyllacto-N-tetraose, DSLNT)与WAZ显著负相关(β=-0.36～-0.25,P<0.05)。总中性非岩藻基HMOs和乳糖-N-四糖(lacto-N-tetraose, LNT)亦与年龄别身长(length for age Z-score, LAZ)和WAZ呈负相关(β=-0.33～-0.25,P<0.05)。在分泌型/路易斯基因型阳性(secretor+/Lewis+, Se+Le+)母亲中，总HMOs和唾液酸化HMOs对婴儿WLZ、WAZ和BAZ的负向效应进一步强化(β=-1.22～-0.48,P<0.05)。结论 产后6个月内特定母乳低聚糖浓度与婴儿不同生长指标存在关联，其中总HMOs、唾液酸化HMOs和中性非岩藻基化HMOs与婴儿体重指标呈负相关。
Abstract：OBJECTIVE To investigate the relationship between human milk oligosaccharides(HMOs) levels in healthy mothers and infant physical growth.METHODS Based on a nationally representative, multi-stage stratified sampling cross-sectional survey on human milk composition, 195 lactating women within 6 months postpartum and their infants were enrolled. Human milk oligosaccharide(HMOs) concentrations were quantified using ultra-high performance liquid chromatography-tandem mass spectrometry(UHPLC-MS/MS). Infant anthropometric measurements(height, weight, and head circumference) were collected to calculate Z-scores. Associations between HMOs and infant growth were analyzed via general linear models.RESULTSTotal HMOs and total sialylated HMOs in mature breast milk showed negative correlations with weight for length Z-score(WLZ), weight for age Z-score(WAZ), and BMI for age Z-score(BAZ)(β=-0.80 to-0.25, P<0.05). Specifically, 6′-sialyllactosamine(6′-SL), sialyllacto-N-tetraose c(LSTc), and disialyllacto-N-tetraose(DSLNT) demonstrated significant negative associations with WAZ(β=-0.36 to-0.25, P<0.05). Total neutral non-fucosylated HMOs and lacto-N-tetraose(LNT) were also negatively correlated with length for age Z-score(LAZ) and WAZ(β=-0.33 to-0.25, P<0.05). Among secretor+/Lewis+(Se+Le+) mothers, the negative effects of total HMOs and sialylated HMOs on infant WLZ, WAZ, and BAZ were further strengthened(β=-1.22 to-0.48, P<0.05).CONCLUSION Specific HMO concentrations in human milk during the first 6 months postpartum are associated with infant growth outcomes. Total HMOs, sialylated HMOs, and neutral non-fucosylated HMOs demonstrate negative associations with weight indicators.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2025.03.002
中图分类号:R174.4
引用信息:
[1]周钰,姜珊,王淑霞,等.母乳低聚糖水平与6月龄内婴儿体格生长的关系[J].卫生研究,2025,54(03):358-365.DOI:10.19813/j.cnki.weishengyanjiu.2025.03.002.
基金信息:
国家重点研发计划(No.2022YFF1100401)
2025-05-21
2025-05-21