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目的探讨河南新密农村地区妇女生活方式、膳食因素与高危型人乳头瘤病毒(HR-HPV)持续感染的关系。方法于2010年在河南新密进行前瞻性的研究,使用不同HR-HPV DNA检测方法对2500名妇女进行宫颈癌筛查;2012年和2014年对其中的部分妇女进行随访,并再次进行HR-HPV DNA检测。2014年,收集随访对象的一般人口学信息、妇科信息和过去12个月的膳食摄入情况。结合三次HR-HPV检测结果,判断持续感染情况,将最终纳入研究的721名研究对象分为持续感染组、一过性感染组和全阴性组。用卡方检验比较各因素在各组间的分布差异,以持续感染组为参考水平,用有序logistic回归模型进行危险因素的分析。结果 721名研究对象平均年龄50岁。持续感染组141人(19.56%),一过性感染组180人(24.96%),全阴性组400人(55.48%)。与HR-HPV持续感染相关的因素有:年龄(χ2=58.449,P<0.001,Ptrend<0.001)、吸烟(χ2=6.981,P=0.021)、采取避孕措施(χ2=8.448,P=0.015)、绝经(χ2=35.712,P<0.001)、活产数(χ2=16.340,P<0.001,Ptrend=0.001)及谷类(χ2=17.937,P=0.001)和其他类食物(χ2=12.107,P=0.017)的摄入。将可能的影响因素进行有序logistic回归分析后发现,以最大年龄组(≥59岁)为参考水平,其他三组(年龄由大到小)的OR分别为0.39(95%CI 0.260.59)、0.40(95%CI 0.230.69)和0.28(95%CI0.120.68)。结论年龄是HR-HPV持续感染的最主要的危险因素,控制年龄因素后,生活方式和膳食因素对HR-HPV持续感染的影响不具有显著性。
Abstract：Objective To explore the association between life style,diet intake andhigh risk human papillomavirus( HR-HPV) persistent infection among Chinese rural women living in Xinmi City,Henan Province. Methods In 2010,a 3-year prospective study in which 2500 women were enrolled and screened by different HR-HPV DNA tests was conducted,part of women among them was followed and tested for HR-HPV DNA in2012 and 2014. Furthermore,socio demographic factors,gynecological information and diet intake in the past 12 months were collected by self-designed questionnaire in 2014. A total of 721 women with complete test results were eligible for the final analysis. Study participants were divided into 3 groups( persistent infection group,transient infection group,and negative group) by HR-HPV status,and the association between life style,diet intake and HR-HPV persistence was evaluated using ordinal logistic regression model.Results The average age of 721 women included in the analysis was 50 years old. 141 women had HR-HPV persistent infection,180 women had HR-HPV transient infection,and 400 women were negative for HR-HPV in 3 years. Age( χ2= 58. 449,P < 0. 001,Ptrend< 0. 001),smoking( χ2= 6. 981,P = 0. 021),contraception method( χ2= 8. 448,P = 0. 015),menopause( χ2= 35. 712,P < 0. 001),number of live births( χ2= 16. 340,P < 0. 001,Ptrend< 0. 001),and the intake frequency of cereals( χ2= 17. 937,P =0. 001) or others( χ2= 12. 107,P = 0. 017) varied significantly between women grouped by different HR-HPV status. Compared to women who were older than 59 years,women in the younger groups had a much lower risk of HR-HPV persistence( adjusted OR1= 0. 39,95% CI 0. 26- 0. 59,OR2= 0. 40,95% CI 0. 23- 0. 69,and OR3= 0. 28,95% CI0. 12- 0. 68). Conclusion Age is the main risk factor of HR-HPV persistent infection.Lifestyle,diet intake do not associate with HR-HPV persistence after adjustment by age.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2016.01.006
中图分类号:R173
引用信息:
[1]雷晓琴,陈汶,于露露,等.河南新密农村地区妇女生活方式、膳食因素与高危型HPV持续感染的关系研究[J].卫生研究,2016,45(01):45-50.DOI:10.19813/j.cnki.weishengyanjiu.2016.01.006.
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2016-01-30