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大豆素在肠道细菌作用下可产生二氢大豆素、雌马酚、ODMA。分别有30%～55%的人能产生雌马酚。肠道生理、宿主基因、膳食因素可能与雌马酚产生的个体差异有关,但雌马酚产生的影响因素尚未明确。某些大豆摄入量高的人群研究表明,尿液和血清雌马酚浓度与乳腺癌及前列腺癌发生呈负相关关系。大豆补充剂与骨密度研究提示,在雌马酚产生者中,大豆产品对骨密度保持更有效。雌马酚产生的影响因素及雌马酚与人类健康间的关系尚需进一步确定。
Abstract：Under the function of human intestinal bacteria,soybean can produce equol and O-desmethylangolensin.Among humans,30% ～ 55% have the bacteria capable of producing equol.Factors that influence the capacity to produce equol are not clearly established;however,gut physiology,host genetics,and diet factors are probably related to the individual difference of equol producing.Some studies on high soy-consuming populations reported an inverse association between urinary and serum equol concentrations and breast and prostate cancer risk.Furthermore,several studies of soy supplementation and bone density suggest that soy products may be more effective in maintaining bone density in equol-producing individuals.It requires further identification of the factors influencing the equol producing and the relationship between equol and human health.
1LAMPE J W,CHANG J L.Interindividual differences inphytochemical metabolism and disposition[J].Semin Cancer Biol,2007,17(5):347-353.
2ATKINSON C,FRANKENFELD C L,LAMPE J W.Gut bacterial metabolism of the soy isoflavone daidzein:exploring the relevance to human health[J].Exp Biol Med,2005,230(3):155-170.
3TAMURA A,SHIOMI T,HACHIYA S,et al.Low activities of intestinal lactase suppress the early phase absorption of soy isoflavones in Japanese adults[J].Clin Nutr,2008,27(2):248-253.
4ATKINSON C,NEWTON K M,BOWLES E J,et al.Demographic,anthropometric,and lifestyle factors and dietary intakes in relation to daidzein-metabolizing phenotypes among premenopausal women in the United States[J].Am J Clin Nutr,2008,87(3):679-687.
5FRANKENFELDC L,ATKINSON C,THOMAS W K,et al.High concordance of daidzein-metabolizing phenotypes in individuals measured1to3years apart[J].Br J Nutr,2005,94(6):873-876.
6FLATZ G,CZEIZEL A,METNEKI J,et al.Pulmonary hydrogen and methane excretion following ingestion of an unabsorbable carbohydrate:a study of twins[J].J Pediatr Gastroenterol Nutr,1985,4(6):936-941.
7FRANKENFELD C L,ATKINSON C,THOMAS W K,et al.Familial correlations,segregation analysis,and nongenetic correlates of soy isoflavonemetabolizing phenotypes[J].Exp Biol Med,2004,229(11):902-913.
8SETCHELL K D R,BROWN N M,LYDEKING-OLSEN E.The clinical importance of the metabolite equol:a clue to the effectiveness of soy and its isoflavones[J].J Nutr,2002,132(12):3577-3584.
9LAMPE J W,KARR S C,HUTCHINS A M,et al.Urinary equol excretion with a soy challenge:influence of habitual diet[J].Proc Soc Exp Biol Med,1998,217(3):335-339.
10ROWLAND I R,WISEMEN H,SANDERS T A B,et al.Interindividual variation in metabolism of soy isoflavones and lignans:influence of habitual diet on equol production by the gut microflora[J].Nutr Cancer,2000,36(1):27-32.
11ARAI Y,UEHARA M,SATO Y,et al.Comparison of isoflavones among dietary intake,plasma concentration and urinary excretion for accurate estimation of phytoestrogen intake[J].J Epidemiol,2000,10(2):127-135.
12王路,赵海田,程翠林,等.大豆异黄酮代谢产物——雌马酚对更年期症状的影响研究[J].卫生研究,2009,38(1):117-119.
13刘宝花,刘爱萍,内山成人,等.北京地区成人雌马酚代谢表型及其影响因素研究[J].卫生研究,2010,39(1):59-64.
14HEDLUND T E,MARONI P D,FERUCCI P G,et al.Long-term dietary habits affect soy isoflavone metabolism and accumulation in prostatic fluid in caucasian men[J].J Nutr,2005,135(6):14001406.
15MIYANAGA N,AKAZA H,TAKASHIMA N,et al.Higher consumption of green tea may enhance equol production[J].Asian Pac J Cancer Prev,2003,4(4):297-301.
16ADLERCREUTZ H,HONJO H,HIGASHI A,et al.Urinary excretion of lignans and isoflavonoid phytoestrogens in Japanese men and women consuming a traditional Japanese diet[J].Am J Clin Nutr,1991,54(6):1093-1100.
17OZASA K,NAKAO M,WATANABE Y,et al.Association of serum phytoestrogen concentration and dietary habits in a sample set of the JACC Study[J].J Epidemiol,2005,15(Suppl2):S196-S202.
18SETCHELL K D,COLE S J.Method of defining equol-producer status and its frequency among vegetarians[J].J Nutr,2006,136(8):2188-2193.
19BOLCA S,POSSEMIERS S,HERREGAT A,et al.Microbial and dietary factors are associated with the equol producer phenotype in healthy postmenopausal women[J].J Nutr,2007,137(10):22422246.
20NAGATA C,UENO T,UCHIYAMA S,et al.Dietary and lifestyle correlates of urinary excretion status of equol in Japanese women[J].Nutr Cancer,2008,60(1):49-54.
21SONG K B,ATKINSON C,FRANKENFELD C L,et al.Prevalence of daidzeinmetabolizing phenotypes differs between Caucasian and Korean American women and girls[J].J Nutr,2006,136(5):1347-1351.
22FRANKENFELD C L,MCTIERNAN A,AIELLO E J,et al.Mammographic density in relation to daidzein-metabolizing phenotypes in overweight,postmenopausal women[J].Cancer Epidemiol Biomarkers Prev,2004,13(7):1156-1162.
23FUHRMAN B J,TETER B E,BARBA M,et al.Equol status modifies the association of soy intake and mammographic density in a sample of postmenopausal women[J].Cancer Epidemiol Biomarkers Prev,2008,17(1):33-42.
24UESUGI S,WATANABE S,ISHIWATA N,et al.Effects of isoflavone supplements on bone metabolic markers and climacteric symptoms in Japanese women[J].Biofactors,2004,22(1-4):221228.
25WU J,OKA J,HIGUCHI M,et al.Cooperative effects of isoflavones and exercise on bone and lipid metabolism in postmenopausal Japanese women:a randomized placebo-controlled trial[J].Metabolism,2006,55(4):423-433.
26BRINK E,COXAM V,ROBINS S,et al.Long-term consumption of isoflavone-enriched foods does not affect bone mineral density,bone metabolism,or hormonal status in early postmenopausal women:a randomized,double-blind,placebo controlled study[J].Am J Clin Nutr,2008,87(3):761-770.
27CLERICI C,SETCHELL K D,BATTEZZATI P M,et al.Pasta naturally enriched with isoflavone aglycons from soy germ reduces serum lipids and improves markers of cardiovascular risk[J].J Nutr,2007,137(10):2270-2278.
28BADEAU R,JAUHIAINEN M,METSO J,et al.Effect of isolated isoflavone supplementation on ABCA1-dependent cholesterol efflux potential in postmenopausal women[J].Menopause,2007,14(7):293-299.
29VRIELING A,ROOKUS M A,KAMPMAN E,et al.Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk[J].J Nutr,2007,137(2):379-383.
30NICULESCU M D,POP E A,FISCHER L M,et al.Dietary isoflavones differentially induce gene expression changes in lymphocytes from postmenopausal women who form equol as compared with those who do not[J].J Nutr Biochem,2007,18(6):380-390.
31ATKINSON C,NEWTON K M,STANCZYK F Z,et al.Daidzeinmetabolizing phenotypes in relation to serum hormones and sex hormone binding globulin,and urinary estrogen metabolites in premenopausal women in the United States[J].Cancer Causes Control,2008,19(10):1085-1093.
32TRMALA R M,APPT S,CLARKSON T B,et al.Individual differences in equol production capability modulate blood pressure in tibolone-treated postmenopausal women:lack of effect of soy supplementation[J].Climacteric,2007,10(6):471-479.
基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2010.06.040
中图分类号:R151
引用信息:
[1]刘宝花,秦立强,王培玉.雌马酚与大豆健康效应关系的研究进展[J].卫生研究,2010,39(06):784-786.DOI:10.19813/j.cnki.weishengyanjiu.2010.06.040.
基金信息:
国家自然科学基金项目(No.30872114)
2010-11-30
2010-11-30