| 259 | 0 | 84 |
| 下载次数 | 被引频次 | 阅读次数 |
植物化学物是从水果蔬菜等植物中提取的除维生素以外的对人体有益的化合物,已有研究表明其对多种癌症治疗具有促进作用。铁死亡是由于细胞内活性氧大量生成和大量亚铁离子积累导致的脂质过氧化引起的细胞膜破坏导致的细胞死亡,是一种新型程序性细胞死亡方式。许多植物化学物可以通过对铁死亡的调节应用于胃癌的治疗中。本文综述了通过靶向铁死亡途径对胃癌发生发展产生作用的植物化学物及其可能机制。
Abstract:[1] HAN B,ZHENG R,ZENG H,et al.Cancer incidence and mortality in China,2022 [J].J Natl Cancer Cent,2024,4(1):47-53.
[2] BRAY F,LAVERSANNE M,SUNG H,et al.Global cancer statistics 2022:GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries [J].CA Cancer J Clin,2024,74(3):229-263.
[3] DIXON S J,LEMBERG K M,LAMPRECHT M R,et al.Ferroptosis:an iron-dependent form of nonapoptotic cell death [J].Cell,2012,149(5):1060-1072.
[4] YU H,GUO P,XIE X,et al.Ferroptosis,a new form of cell death,and its relationships with tumourous diseases [J].J Cell Mol Med,2016,21(4):648-657.
[5] KHAN F,PANDEY P,VERMA M,et al.Emerging trends of phytochemicals as ferroptosis modulators in cancer therapy [J].Biomed Pharmacother,2024,173:116363.
[6] CHEN X,KANG R,KROEMER G,et al.Broadening horizons:the role of ferroptosis in cancer [J].Nat Rev Clin Oncol,2021,18(5):280-296.
[7] YANG W S,SRIRAMARATNAM R,WELSCH MATTHEW E,et al.Regulation of ferroptotic cancer cell death by GPX4 [J].Cell,2014,156(1-2):317-331.
[8] FANG X,ARDEHALI H,MIN J,et al.The molecular and metabolic landscape of iron and ferroptosis in cardiovascular disease [J].Nat Rev Cardiol,2022,20(1):7-23.
[9] SUN K,LI C,LIAO S,et al.Ferritinophagy,a form of autophagic ferroptosis:new insights into cancer treatment [J].Front Pharmacol,2022,13:1043344.
[10] MISHIMA E,CONRAD M.Nutritional and metabolic control of ferroptosis [J].Annu Rev Nutr,2022,42(1):275-309.
[11] YANG W S,KIM K J,GASCHLER M M,et al.Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis [J].Proc Natl Acad Sci USA,2016,113(34):e4966-4975.
[12] LIU T,ZHU Y,WANG J,et al.Antibacterial effects and mechanisms of quercetin-β-cyclodextrin complex mediated photodynamic on Escherichia coli O157:H7 [J].Arch Microbiol,2024,206(11):445.
[13] DING L,DANG S,SUN M,et al.Quercetin induces ferroptosis in gastric cancer cells by targeting SLC1A5 and regulating the p-Camk2/p-DRP1 and NRF2/GPX4 Axes [J].Free Radic Biol Med,2024,213:150-163.
[14] LIU Y,SONG Z,LIU Y,et al.Identification of ferroptosis as a novel mechanism for antitumor activity of natural product derivative a2 in gastric cancer [J].Acta Pharm Sin B,2021,11(6):1513-1525.
[15] TIAN Y,GONG G Y,MA L L,et al.Anti-cancer effects of polyphyllin I:an update in 5 years [J].Chem Biol Interact,2020,316:108936.
[16] ZHENG F,WANG Y,ZHANG Q,et al.Corrigendum:polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis [J].Front Pharmacol,2023,14:1201715.
[17] MORI S,FUJIWARA-TANI R,GYOTEN M,et al.Berberine induces combined cell death in gastrointestinal cell lines [J].Int J Mol Sci,2023,24(7):6588.
[18] WEN Z,ZHANG Y,GAO B,et al.Baicalin induces ferroptosis in oral squamous cell carcinoma by suppressing the activity of FTH1 [J].J Gene Med,2024,26(2):e3669.
[19] POURHANIFEH M H,FARROKHI-KEBRIA H,MOSTANADI P,et al.Anticancer properties of baicalin against breast cancer and other gynecological cancers:therapeutic opportunities based on underlying mechanisms [J].Curr Mol Pharmacol,2024,17:e18761429263063.
[20] WANG J,WU Z,PENG J,et al.Multiple roles of baicalin and baicalein in the regulation of colorectal cancer [J].Front Pharmacol,2024,15:1264418.
[21] YUAN J,KHAN S U,YAN J,et al.Baicalin enhances the efficacy of 5-Fluorouracil in gastric cancer by promoting ROS-mediated ferroptosis [J].Biomed Pharmacother,2023,164:114986.
[22] KADASAH S F,RADWAN M O.Overview of ursolic acid potential for the treatment of metabolic disorders,autoimmune diseases,and cancers via nuclear receptor pathways [J].Biomedicines,2023,11(10):2845.
[23] LI H,YU Y,LIU Y,et al.Ursolic acid enhances the antitumor effects of sorafenib associated with Mcl-1-related apoptosis and SLC7A11-dependent ferroptosis in human cancer [J].Pharmacol Res,2022,182:106306.
[24] GAO S,LIU Z,LI H,et al.Cardiovascular actions and therapeutic potential of tanshinone IIA [J].Atherosclerosis,2012,220(1):3-10.
[25] DONG X,DONG J,PENG G.Growth-inhibiting and apoptosis-inducing effects of Tanshinone II A on human gastric carcinoma cells [J].J Huazhong Univ Sci Technolog Med Sci,2007,27(6):706-709.
[26] GUAN Z,CHEN J,LI X,et al.Tanshinone IIA induces ferroptosis in gastric cancer cells through p53-mediated SLC7A11 down-regulation [J].Biosci Rep,2020,40(8):BSR20201807.
基本信息:
DOI:10.19813/j.cnki.weishengyanjiu.2025.06.024
中图分类号:R735.2
引用信息:
[1]马欣欣,李娟,刘家仁.铁死亡与植物化学物在胃癌中的研究进展[J].卫生研究,2025,54(06):1041-1044.DOI:10.19813/j.cnki.weishengyanjiu.2025.06.024.
基金信息:
国家自然科学基金(No.82172580)
2024-11-27
2024
2025-02-26
2025
2
2025-11-14
2025-11-14