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目的探讨55岁及以上人群轻度认知功能障碍与高尿酸血症现状及其相关性。方法以"神经系统疾病专病社区队列研究"2018—2019年基线调查数据资料为基础,采用多阶段分层整群随机抽样的方法在河北、浙江、陕西及湖南省选取4272名55岁及以上人群作为研究对象,使用蒙特利尔认知评估量表(Montreal cognitive assessment,MoCA)来评价人群轻度认知功能障碍情况并检测空腹血清尿酸水平,计算人群血清尿酸水平与MoCA得分的相关性,采用多变量Logistic回归模型分析血清尿酸水平对人群轻度认知障碍的影响。结果血清尿酸正常组和高尿酸血症组的55岁及以上人群认知功能障碍患病率分别为38.6%和38.4%;血清尿酸正常组中,非认知功能障碍人群的血清尿酸水平为291.4μmol/L,认知功能障碍人群的血清尿酸水平为283.7μmol/L,非认知功能障碍人群的血清尿酸水平显著高于认知功能障碍人群(F=16.12,P<0.05),且该组研究对象MoCA分值与其血清尿酸水平呈显著正相关(r=0.103,P<0.05);高尿酸血症组中,非认知功能障碍人群的血清尿酸水平为450.9μmol/L,认知功能障碍人群的血清尿酸水平为442.4μmol/L,非认知功能障碍人群与认知功能障碍人群血清尿酸水平差异无统计学意义(F=2.44,P>0.05),且该组研究对象MoCA分值与其血清尿酸水平亦无相关性(r=0.064,P>0.05)。Logistic回归模型分析结果显示,55岁及以上人群患有高尿酸血症不是其患认知功能障碍的危险因素(OR=1.04, 95%CI 0.87～1.25,P=0.630)。结论血清尿酸在正常值范围内,适当提高血清尿酸水平可能会对轻度认知功能障碍具有保护作用;未发现高尿酸血症会增加55岁及以上人群患认知功能障碍的风险。
Abstract：OBJECTIVE To explore the association between mild cognitive impairment and hyperuricemia among people aged 55 and above. METHODS Based on the baseline survey data of "community cohort study on neurological diseases" from 2018 to 2019, 4272 residents aged 55 and above with complete data of individual socioeconomic status, lifestyle, mild cognitive impairment and serum uric acid level were selected as the research objects. The Montreal cognitive assessment(MoCA) was used to evaluate the mild cognitive impairment of the research objects. The relationship between serum uric acid level and MoCA score was analyzed. Multivariate Logistic regression model was used to analyze the association of serum uric acid level and mild cognitive impairment. RESULTS The prevalence of cognitive impairment in the normal and high serum uric acid groups were 38.6% and 38.4%, respectively. In the normal serum uric acid level group, the serum uric acid level of the non-cognitive impairment group was significantly higher(291.4 μmol/L)than that of the cognitive impairment group(283.7 μmol/L)(F=16.12, P<0.05), and the MoCA score of the subjects in this group was significantly positively correlated with the serum uric acid level(r=0.103,P<0.05). In the hyperuricemia group, no significant difference was found in serum uric acid level between non-cognitive impairment group(450.9 μmol/L) and cognitive impairment group(442.4 μmol/L)(F=2.44, P>0.05), and there was no correlation between MoCA score and serum uric acid level(r=0.064, P>0.05). Logistic regression analysis showed that hyperuricemia was not a risk factor for cognitive impairment in people aged 55 and above(OR=1.04, 95% CI 0.87-1.25, P=0.630). CONCLUSION Within the normal range of serum uric acid, appropriate increase of serum uric acid may play a protective role in cognitive impairment. Hyperuricemia has not been found to increase the risk of cognitive impairment in people 55 years and older.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2021.01.003
中图分类号:R749.1;R589.7
引用信息:
[1]苏畅,胡丹标,王辛,等.中国四省55岁及以上人群轻度认知功能障碍与高尿酸血症的关联性[J].卫生研究,2021,50(01):8-14.DOI:10.19813/j.cnki.weishengyanjiu.2021.01.003.
基金信息:
国家重点研发计划[神经系统专病队列研究项目(No.2017YFC0907700);神经系统疾病专病社区队列研究(No.2017YFC0907701)]
2021-01-22
2021-01-22