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目的 探索中国成年人甘油三酯葡萄糖(triglyceride-glucose, TyG)指数与高血压发病风险的关系。方法 利用中国居民营养与健康随访研究(2021)数据，该研究于2021年5月—2022年12月开展，以2010—2012年中国居民营养与健康状况监测为基线，在31个省(自治区、直辖市)150个监测点的基础上，采用分层系统抽样的方法选取10个调查点，纳入基线血压正常的2516名研究对象。随访收集其人口学基本信息、体格、生活行为和血生化指标等数据。使用基线空腹血清甘油三酯及血糖计算TyG指数，并按四分位分组(Q1～Q4)。采用多重调整Logistic回归检验TyG指数与高血压发病风险的关联，并将人口学基本信息、体格、生活行为和油盐摄入等作为协变量纳入模型，限制性立方样条模型分析TyG指数与高血压发病的剂量-反应关系，分层分析和交互作用检验评估TyG与高血压不同亚组的交互作用。结果 调查对象基线年龄为(52.31±12.14)岁，其中男性45.99%,女性54.01%。基线TyG指数为8.53±0.67,随访后高血压发病率57.95%,TyG指数与高血压发病呈显著正相关趋势(β=1.51,P<0.05)。TyG指数四分位分组(Q1～Q4)发病率也呈递增趋势，与Q1组比，Q2、Q3和Q4组发病风险分别为1.28倍(95%CI 1.01～1.62,P<0.04)、1.39倍(95%CI 1.09～1.76,P=0.01)和2.11倍(95%CI 1.64～2.71,P<0.01)。限制性立方样条分析提示TyG指数与高血压发病呈正向线性关系(总体检验P<0.01,非线性关联检验P=0.54)。TyG指数与高血压发病的正向关联在不同年龄、性别、城乡、文化程度、家庭收入、二手烟暴露、身体活动、高血压家族史、烹调盐、烹调油摄入量、超重/肥胖和中心型肥胖亚组中保持稳定(P<0.05)。结论 TyG指数与高血压发病呈显著正相关趋势。
Abstract：OBJECTIVE To explore the relationship between the triglyceride-glucose(TyG) index and the risk of new onset hypertension in Chinese adults aged 18 and above.METHODS Data was extracted from follow-up study for Nutrition and Health of Chinese Residents(2021),which was conducted from May 2021 to December 2022. Stratified systematic sampling method was used to select 10 survey sites from 150 surveillance sites based on the Chinese Nutrition and Health Surveillance 2010-2012. demographic information, physical status, lifestyle were collected through questionnaire, physical measurements and laboratory tests. The TyG index was calculated using baseline fasting serum triglyceride and blood glucose, and was divided into quartiles(Q1-Q4). Multiple-adjusted logistic regression was used to test the association between the TyG index and the risk of hypertension, after adjusting for basic demographic information, physical characteristics, lifestyle behaviors, and intake of oil and salt. The restricted cubic spline model was applied to analyze the dose-response relationship between the TyG index and hypertension. Stratified analysis and interaction tests were conducted to evaluate the interaction in different subgroups.RESULTS A total of 2516 subjects with normal blood pressure at baseline was included, with mean TyG of 8.53±0.67 on baseline. And the rate of new onset hypertension was 57.95%. Significantly positive correlation trend was observed between the TyG index and hypertension(β=1.51, P<0.05). Consistently, high levels of TyG index were significantly associated with increased risk of new-onset hypertension when TyG index was grouped into quartiles. Compared with Q1, the risks were 1.28 times(95%CI 1.01-1.62,P<0.04), 1.39 times(95%CI 1.09-1.76, P=0.01), and 2.11 times(95%CI 1.64-2.71, P<0.01)in Q2-Q4, respectively. Restricted cubic spline analysis suggested a positive linear relationship between the TyG index and the incidence of hypertension(Poverall<0.01,Pnonlinear = 0.54). The associations were consistent in various subgroups(P<0.05) such as age, gender, living area, education, household income, second-hand smoking, physical activity, family history of hypertension, cooking salt and oil intake, overweight and obesity, and central obesity.CONCLUSION High TyG index was significantly associated with an increased risk of hypertension among Chinese adults.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2025.04.004
中图分类号:R544.1
引用信息:
[1]蔡姝雅,杨宇祥,满青青等.甘油三酯葡萄糖指数与高血压发病风险的关系[J].卫生研究,2025,54(04):549-556+565.DOI:10.19813/j.cnki.weishengyanjiu.2025.04.004.
基金信息:
国家财政项目(No.102393220020070000012); 国家建设高水平大学公派研究生项目(No.202408110159)