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高尿酸血症作为一种典型的代谢性疾病,源于体内嘌呤代谢紊乱,主要由于尿酸生成过剩或排泄障碍所致,被视为心血管疾病、糖尿病、高血压、血脂异常、慢性肾病等诸多健康威胁的关键促发因素。自21世纪以来,高尿酸血症的研究领域不断拓展,其模型构建策略虽日趋丰富但尚未能充分贴近临床实践的复杂情境,且领域内尚缺乏统一、标准化的评估体系。因此,本文对高尿酸血症及相关并发症的细胞与动物模型的建立方法进行综述,为深入理解该病的发病机制以及探索创新性的治疗途径奠定理论基础和实验参考。
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基本信息:
DOI:10.19813/j.cnki.weishengyanjiu.2026.01.026
中图分类号:R589.7;R-332
引用信息:
[1]黄莹,刘雪坤,郭鑫.高尿酸血症及并发症的细胞与动物模型建立[J].卫生研究,2026,55(01):159-164+172.DOI:10.19813/j.cnki.weishengyanjiu.2026.01.026.
基金信息:
吉林省自然科学基金(No.YDZJ202501ZYTS671); 吉林省教育厅科学研究项目(No.JJKH20251426KJ); 吉林省卫生健康科技能力提升计划项目(No.2025ZY-ZA001); 通化师范学院校级科研项目(No.2025033ND)
2026-01-21
2026-01-21