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目的了解福建省漳州市和广东省中山市儿童青少年中胰岛素抵抗指数(HOMA-IR)的分布情况。方法从福建省漳州市区和广东省中山市区分层随机抽取6~18周岁儿童青少年3102名[男孩1574名(50.74%),女孩1528名(49.26%)]进行横断面研究,分别测量其身高、体重、空腹血糖和空腹胰岛素并计算BMI和HOMA-IR。结果空腹血糖、空腹胰岛素水平在6~18周岁阶段随着年龄的增加逐渐增加,但性别差异无统计学意义;BMI随年龄增加而增加,12~15岁女孩的BMI高于同年龄段的男孩(P<0.05),16岁之后男孩的BMI高于女孩(P<0.05);HOMA-IR在6~12岁之间都随年龄的增加而增加,12岁之后,HOMA-IR指数处于高位,男女差异无统计学意义。结论空腹血糖、空腹胰岛素、HOMA-IR随年龄变化而变化,评价儿童胰岛素抵抗应基于不同年龄段该HOMA-IR的某一百分位数,而不是由单一切割值来确定。
Abstract：Objective To investigate the distribution of the homeostasis model assessment of insulin resistance( HOMA-IR) among children and adolescent in Zhangzhou city and Zhongshan city. Methods Total of 3102 children and adolescent aged 6 to 18-year-old were recruited,which were enrolled in a population-based cross-sectional study.Anthropometric and biochemical parameters were measured. Results A total of 1528( 49. 26%) girls and 1574( 50. 74%) boys were included in this study. The concentrations of insulin and fasting glucose gradually increased from 6 to 18 years of age,there was no statistical difference between boys ang girls. The mean values for the BMI were similar in age-matched boys and girls from 6 to 18-year-old,but for 12 to 15-year-old children was significantly higher in the girls compared with the boys and conversely for 16 to 18-year-old( P < 0. 05). The HOMA-IR gradually increased with age and reached a plateau at 12 years of age and there was no markedly differential in gender. Conclusion The glucose levels,insulin concentrations and HOMA-IR exhibited a gradual increase with age. It was suggested that the evaluation of IR in children should be based on percentiles of the HOMA-IR rather than a dichotomous value derived from a single cutoff point.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2015.04.008
中图分类号:R725.8
引用信息:
[1]何金水,林国模,张玉贵,等.漳州市和中山市儿童青少年胰岛素抵抗指数分布情况[J].卫生研究,2015,44(04):555-558.DOI:10.19813/j.cnki.weishengyanjiu.2015.04.008.
2015-07-30
2015-07-30