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目的 探索MTHFR与MTRR基因多态性与妊娠期高血压疾病的关联性。方法 选取2021年7月至2022年12月武汉市某大型三甲医院的孕产妇作为研究对象，分为妊娠期高血压患病组(141例)与对照组(1540例)。收集孕产妇一般个人信息，MTHFR、MTRR基因多态性及妊娠期高血压疾病的临床诊断结果。采用χ2检验比较病例组与对照组间基因型的分布差异性，采用多因素逐步Logistic回归分析MTHFR与MTRR基因多态性与妊娠期高血压疾病的关联性。结果 研究对象年龄(30.55±3.55)岁。MTHFR基因C677T位点的CT基因型与CC型相比，发生妊娠期高血压疾病的风险下降(OR=0.57,95%CI 0.39～0.84)。结论 MTHFR(C677T)基因多态性、孕前体质指数、高血压家族史与妊娠期高血压疾病的发病风险显著相关。
Abstract：[1] 颜雪梅，孔繁娟，王爱华，等.2012—2019年妊娠期高血压疾病流行现状及妊娠结局分析 [J].中国生育健康杂志，2021,32(3):252-256.
[2] YE C,RUAN Y,ZOU L,et al.The 2011 survey on hypertensive disorders of pregnancy (HDP) in China:prevalence,risk factors,complications,pregnancy and perinatal outcomes [J].PloS One,2014,9(6):e100180.
[3] LEWANDOWSKA M,WI■CKOWSKA B,SAJDAK S.Pre-pregnancy obesity,excessive gestational weight gain,and the risk of pregnancy-induced hypertension and gestational diabetes mellitus [J].J Clin Med,2020,9(6):1980.
[4] ZHUANG C,GAO J,LIU J,et al.Risk factors and potential protective factors of pregnancy-induced hypertension in China:a cross-sectional study [J].J Clin Hypertens,2019,21(5):618-623.
[5] 赵芳，朱志敏，王婷婷，等.孕妇血清细胞因子及同型半胱氨酸水平与妊娠期高血压疾病的相关性研究 [J].心脏杂志，2022(6):665-667.
[6] 谢铭，曾媛，袁姝倩，等.超重/肥胖与高同型半胱氨酸血症的交互作用对高血压发病的影响 [J].中华疾病控制杂志，2021,25(11):1269-1275.
[7] RAGHUBEER S,MATSHA T E.Methylenetetrahydrofolate (MTHFR),the one-carbon cycle,and cardiovascular risks [J].Nutrients,2021,13(12):4562.
[8] LI D,ZHAO Q,HUANG X,et al.Association of genetic and epigenetic variants in one-carbon metabolism gene with folate treatment response in hyperhomocysteinaemia [J].Eur J Clin Nutr,2020,74(7):1073-1083.
[9] 林建华，吕鑫.妊娠期高血压疾病的处理难点和困惑：妊娠期高血压疾病诊治指南(2020)解读 [J].四川大学学报(医学版),2022,53 (6):1007-1011.
[10] WU K R,ZHANG S F,GUAN Z W,et al.Methylenetetrahydrofolate reductase gene polymorphism C677T is associated with increased risk of coronary heart disease in Chinese type 2 diabetic patients [J].Chin Med Sci J,2021,36(2):103-109.
[11] 林煊，吴昊，徐雪琴，等.温州地区2743例育龄女性MTHFR C677T基因多态性分析 [J].中国优生与遗传杂志，2024,32 (3):593-596.
[12] SONG J,HOU J,ZHAO Q,et al.Polymorphism of MTHFR C677T gene and the associations with the severity of essential hypertension in Northern Chinese population [J].Int J Hypertens,2020:1878917.
[13] QIAN X L,CAO H,ZHANG J,et al.The prevalence,relative risk factors and MTHFR C677T genotype of H type hypertension of the elderly hypertensives in Shanghai,China:a cross-section study:prevalence of H type hypertension [J].BMC Cardiovasc Disord,2021,21(1):376.
[14] 王慧，刘岩岩，张裕，等.MTHFR基因多态性与儿童原发性高血压的相关性研究 [J].中国当代儿科杂志，2022,24(5):579-584.
[15] 王伟华，胡晓梅，黄冬梅，等.叶酸代谢相关酶基因多态性与妊娠期高血压疾病的相关性分析[J].中国民康医学，2022,34 (4):1-3.
[16] 胡勤，徐梅，叶强，等.叶酸代谢相关酶基因与妊娠期糖尿病、妊娠期高血压、羊水过少及早产的关系研究 [J].检验医学与临床，2021,18 (9):1257-1261.
[17] 孕期妇女膳食指南 [J].中华围产医学杂志，2016,19(9):641-648.
[18] BIBBINS-DOMINGO K,GROSSMAN D C,CURRY S J,et al.Folic acid supplementation for the prevention of neural tube defects:US preventive services task force recommendation statement [J].JAMA,2017,317(2):183-189.
[19] ZHANG Y,LI J,SUN N,et al.Precision folic acid trial to lower homocysteine (PFAT-Hcy) trial investigators.Optimal folic acid dosage in lowering homocysteine:precision folic acid trial to lower homocysteine (PFAT-Hcy) [J].Eur J Nutr,2024.
基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2024.05.004
中图分类号:R714.246
引用信息:
[1]程瑶,孙国强,杨丽君.MTHFR和MTRR基因多态性与妊娠期高血压疾病的相关性[J].卫生研究,2024,53(05):707-710.DOI:10.19813/j.cnki.weishengyanjiu.2024.05.004.
基金信息:
国家重点研发计划(No.2018YFC1004304); 湖北省妇幼保健院科研项目(No.2021SFYM007)
2024-09-05
2024-09-05