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老年神经退行性疾病如帕金森病和阿尔茨海默病等均为多病因的复杂性疾病,在临床上单一作用靶点的药物治疗效果有限。绿茶多酚以其清除自由基、鳌合金属离子和调节神经细胞内蛋白激酶通路等作用在老年神经退行性疾病的防治中具有很大的潜力,本文就近年来该方面的研究进展进行阐述。
Abstract：Considering the multi-etiological characters of neurodegenerative disorders such as Parkinson's disease and Alzheimer's disease,the current pharmacological approaches using drugs oriented towards a single molecular target possess limited ability to modify the course of the diseases.Green tea polyphenols have been reported to possess more than two active neuroprotective-neurorescue moieties that simultaneously manipulate multiple targets involved in neurodegeneration.This review aims to shed light on the multipharmacological neuroprotective activities and the mechanisms of green tea polyphenols on neurodegenerative diseases.
1RAMASSAMY C.Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases:a reviewof their intracellular targets[J].Eur J Pharmacol,2006,545(1):51-64.
2MANACHC,SCALBERTA,MORAND C,et al.Polyphenols:food sources and bioavailability[J].Am J Clin Nutr,2004,79(5):727-747.
3WANG J S,LUO H,WANG P,et al.Validation of green tea polyphenol biomarkers in a phase II human intervention trial[J].Food Chem Toxicol,2008,46(1):232-240.
4SUGANUMA M,OKABE S,ONIYAMA M,et al.Wide distribution of[3H](-)-epigallocatechin gallate,a cancer preventive tea polyphenol,in mouse tissue[J].Carcinogenesis,1998,19(10):1771-1776.
5ABD EL MOHSEN M M,KUHNLE G,RECHNER A R,et al.Uptake and metabolism of epicatechin and its access to the brain after oral ingestion[J].Free Radic Biol Med,2002,33(12):1693-1702.
6CHECKOWAY H,POWERS K,SMITH-WELLE T,et al.Parkinson's disease risks associated with cigarette smoking,alcohol consumption,and caffeine intake[J].Am J Epidemiol,2002,155(8):732-738.
7LEVITES Y,WEINREB O,MAOR G,et al.Green tea polyphenol(-)-epigallocatechin-3-gallate prevents N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced dopaminergic neurodegeneration[J].J Neurochem,2001,78(5):1073-1082.
8CHATURVEDI R K,SHUKLA S,SETH K,et al.Neuroprotective and neurorescue effect of black tea extract in6-hydroxydopamine-lesioned rat model of Parkinson's disease[J].Neurobiol Dis,2006,22(2):421-434.
9MANADEL S A,AMIT T,KALFON L,et al.Targeting multiple neurodegenerative diseases etiologies with multimodal-acting green tea catechins[J].J Nutr,2008,138(8):1578S-1583S.
10KURIYAMA S,HOZAWA A,OHMORI K,et al.Green tea consumption and cognitive function:a cross-sectional study from the Tsurugaya Project1[J].Am J Clin Nutr,2006,83(2):355-361.
11LEVITES Y,AMIT T,MANDEL S,et al.Neuroprotection and neurorescue against Abeta toxicity and PKC-dependent release of nonamyloidogenic soluble precursor protein by green tea polyphenol(-)-epigallocatechin-3-gallate[J].FASEB J,2003,17(8):952-954.
12MANDEL S,AMIT T,REZNICHENKO L,et al.Green tea catechins as brain-permeable,natural iron chelators-antioxidants for the treatment of neurodegenerative disorders[J].Mol Nutr Food Res,2006,50(2):229-234.
13REZAI-ZADEH K,SHYTLE D,SUN N,et al.Green tea epigallocatechin-3-gallate(EGCG)modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in Alzheimer transgenic mice[J].J Neurosci,2005,25(38):8807-8814.
14REZAI-ZADEHK,ARENDASH G W,HOU H,et al.Green tea epigallocatechin-3-gallate(EGCG)reduces beta-amyloid mediated cognitive impairment and modulates tau pathology in Alzheimer transgenic mice[J].Brain Res,2008,1214:177-187.
15BASTIANETTO S,YAO Z X,PAPADOPOULOS V,et al.Neuroprotective effects of green and black teas and their catechin gallate esters against beta-amyloid-induced toxicity[J].Eur J Neurosci,2006,23(1):55-64.
16CHOI Y T,JUNG C H,LEE S R,et al.The green tea polyphenol(-)-epigallocatechin gallate attenuates beta-amyloid-induced neurotoxicity in cultured hippocampal neurons[J].Life Sci,2001,70(5):603-614.
17HAQUE A M,HASHIMOTO M,KATAKURA M,et al.Green tea catechins prevent cognitive deficits caused by Abeta1-40in rats[J].J Nutr Biochem,2008,19(9):619-626.
18OUNJAIJEAN S,THEPHINLAP C,KHANSUWAN U,et al.Effect of green tea on iron status and oxidative stress in iron-loaded rats[J].Med Chem,2008,4(4):365-370.
19GUO Q,ZHAO B,LI M,et al.Studies on protective mechanisms of four components of green tea polyphenols against lipid peroxidation in synaptosomes[J].Biochim Biophys Acta,1996,1304(3):210-222.
20MANDEL S,AMIT T,BAR-AM O,et al.Iron dysregulation in Alzheimer's disease:multimodal brain permeable iron chelating drugs,possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents[J].Prog Neurobiol,2007,82(6):348-360.
21MANDEL S,MAOR G,YOUDIMMB.Iron and alpha-synuclein in the substantia nigra of MPTP-treated mice:effect of neuroprotective drugs R-apomorphine and green tea polyphenol(-)-epigallocatechin-3-gallate[J].J Mol Neurosci,2004,24(3):401-416.
22MANDEL S A,AMITT,KALFON L,et al.Cell signaling pathways and iron chelation in the neurorestorative activity of green tea polyphenols:special reference to epigallocatechin gallate(EGCG)[J].J Alzheimers Dis,2008,15(2):211-222.
23MATTSON M P.Pathways towards and away from Alzheimer'sdisease[J].Nature,2004,430(7000):631-639.
24SMALL D H,NURCOMBE V,REED G,et al.A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth[J].J Neurosci,1994,14(4):2117-2127.
25OBREGON D F,REZAI-ZADEH K,BAI Y,et al.ADAM10activation is required for green tea(-)-epigallocatechin-3-gallate-induced alpha-secretase cleavage of amyloid precursor protein[J].J Biol Chem,2006,281(24):16419-16427.
26JEON S Y,BAE K,SEONG YH,et al.Green tea catechins as a BACE1(beta-secretase)inhibitor[J].Bioorg Med Chem Lett,2003,13(22):3905-3908.
27MANDEL S,WEINREB O,AMITT,et al.Cell signaling pathways in the neuroprotective actions of the green tea polyphenol(-)-epigallocatechin-3-gallate:implications for neurodegenerative diseases[J].J Neurochem,2004,88(6):1555-1569.
28CHEN C,YU R,OWUOR E D,et al.Activation of antioxidant-response element(ARE),mitogen-activated protein kinases(MAPKs)and caspases by major green tea polyphenol components during cell survival and death[J].Arch Pharm Res,2000,23(6):605-612.
29LEVITES Y,AMITT,YOUDIMMB,et al.Involvement of protein kinase C activation and cell survival/cell cycle genes in green tea polyphenol(-)-epigallocatechin3-gallate neuroprotective action[J].J Biol Chem,2002,277(34):30574-30580.
30LEE S Y,LEE J W,LEE H,et al.Inhibitory effect of green tea extract on beta-amyloid-induced PC12cell death by inhibition of the activation of NF-kappaB and ERK/p38MAP kinase pathway through antioxidant mechanisms[J].Brain Res Mol Brain Res,2005,140(1-2):45-54.
31LIU M L,YU L C.Potential protection of green tea polyphenols against ultraviolet irradiation-induced injury on rat cortical neurons[J].Neurosci Lett,2008,444(3):236-239.
32SCALBERT A,JOHNSON I T,SALTMARSH M.Polyphenols:antioxidants and beyond[J].Am J Clin Nutr,2005,81(1Suppl):215S-217S.
33WEINREB O,MANDEL S,YOUDIM M B.cDNA gene expression profile homology of antioxidants and their antiapoptotic and proapoptotic activities in human neuroblastoma cells[J].FASEB J,2003,17(8):935-937.
基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2010.01.041
中图分类号:R285.5
引用信息:
[1]李琼,李勇.绿茶多酚防治老年神经退行性疾病研究进展[J].卫生研究,2010,39(01):123-126.DOI:10.19813/j.cnki.weishengyanjiu.2010.01.041.
基金信息:
国家“十一五”科技支撑计划资助项目(No.2006BAD27B08)
2010-01-30
2010-01-30