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对羟基苯甲酸酯类物质广泛用做食品、药品、化妆品防腐剂,近年国外的研究表明,对羟基苯甲酸酯类物质引起雌性大、小鼠子宫重量增加,影响雄性动物睾丸晚期精子发生,降低仔鼠活产比例与体重,使雄性仔鼠附睾精子数、精子活动度降低。对羟基苯甲酸酯类物质能抑制[3H]17β-雌二醇([3H]E2)与雌激素受体(ER)的结合,并引起两种雌激素依赖细胞株MCF-7和ZR-75-1的增殖,增加MCF-7细胞转染(ERE-CAT受体基因)和内源性(pS2)基因的表达,显示该类物质有弱雌激素活性。
Abstract：Objective Studies indicated that parabens, used as anti-microbial agents in food, cosmetics, and pharmaceuticals, produced a positive uterotrophic response in vivo. They also damaged the late stages of spermatogenesis, altered proportion of pups born alive, and body weight of offspring. They reduced the number of sperm in the epididymis, and the sperm motile activity in male offspring. Parabens could compete with [~3H]17β-estradiol for binding to the estrogen receptor. The proliferation of two estrogen-dependent cell lines MCF-7 and ZR-75-1 could be increased by parabens. They also increased expression of both transfected and endogenous estrogen-regulated genes in MCF-7 cells. The studies demonstrated parabens were weakly estrogenic.
1Soni MG,Taylor SL,Greenberg NA,et al.Evaluation of the health aspects of methyl paraben:a review of the published literature.Food ChemToxicol,2002,40:1335-1373
2Soni MG,Burdock GA,Taylor SL,et al.Safety assessment of propyl paraben:a reviewof the publishedliterature.Food ChemToxicol,2001,39(6):513-532
3Routledge EJ,Parker J,OdumJ,et al.Some alkyl hydroxy benzoate preservatives(parabens)are estrogenic.Toxicol Appl Pharmacol,1998,153:12-19
4Lee CH,Kim HJ.A study on the mechanisms of drugs through membranes.Arch PharmRes,1994,17:182-189
5Hossaini A.Lack of oestrogenic effects of food preservatives(parabens)in uterotrophic assays.Food ChemToxicol,2000,38:319-323
6Darbre PD,Byford JR,Shaw LE,et al.Oestrogenic activity of isobutylparabenin vitroandin vivo.J Appl Toxicol,2002,22:219
7Darbre PD,Byford JR,Shaw LE,et al.Oestrogenic activity of benzylparaben.J Appl Toxicol,2003,23:43-51
8Lemini C,Silva G,Timossi C,et al.Estrogenic effects of p-hydroxybenzoic acidin CD1mice.Environ Res,1997,75(2):130-134
9Oishi S.Effect of butyl paraben onthe male reproductive systemin mice.Arch Toxicol,2002,76(7):423-429
10Oishi S.Effects of butylparaben onthe male reproductive systeminrats.Toxicol Ind Health,2001,17(1):31-39
11Oishi S.Effects of propyl paraben onthe male reproductive system.Food ChemToxicol,2002,40(12):1807-1813
12Blake CA,Boockfor FR.Chronic administration of the environmental pollutant4-tert-octylphenol to adult male ratsinterferes withthe secretion of luteinizing hormone,follicle-stimulating hormone,prolactin,and testosterone.Biol Reprod,1997,57:255-266
13Boockfor FR.,Blake CA.Chronic administration of4-tert-octylphenol to adult male rats causes shrinkage of testes and male accessory sex organs,disrupts spermatogenesis,and increases the incidence of sperm deformities.Biol Reprod,1997,57:268-277
14De Jager C,Bornman MS,van der Horst GI.The effect of p-nonylphenol,and environmental toxicant with oestrogenic propertied,on fertility potential in adult male rats.Andrologia,1999,31:99-106
15Biegel LB,Flaws JA,Hirshfield AN,et al.90-days feeding and one-generation reproduction study in Crl:CD BR rats with17β-estradiol.Toxicol Sci,1998,44:116-142
16Cook JC,Johnson L,O’Connor JC,et al.Effects of17β-estradiol exposure on serum hormone concentrations and testicular parameters in male Crl:CD BRrats.Toxicol Sci,1998,44:155-68
17Kang KS,Che JH,Ryu DY,et al.Decreased spermnumber and motile activity on the F1offspring maternally exposed to butyl p-hydroxybenzoic acid(butyl paraben).J Vet Med Sci,2002,64(3):227-35
18Paris F,Balaguer P,Terouanne B,et al.Phenylphenols,biphenols,bisphenol-A and4-tert-octylphenol exhibit alpha and beta estrogen activities and antiandrogen activity in reporter cell lines.Mol Cell Endocrinol,2002,193(1-2):43-49
19Byford JR,ShawLE,Drew MGB,et al.Oestrogenic activity of parabens in MCF7human breast cancer cells.J Steroid Biochem Mol Biol,2002,80:49-60
20Okubo T,Yokoyama Y,Kano K,et al.ER-dependent estrogenic activity of parabens assessed by proliferation of human breast cancer MCF-7cells and expression of ERalpha and PR.Food ChemToxicol,2001,39(12):1225-1232
21Nishihara T,Nishikawa JI,Kanayama T,et al.Estrogenic activities of517chemicals by yeast two-hybrid assay.J Health Sci,2000,46:282
22Kang KS,Cho SD,Lee YS.Additive estrogenic activities of the binary mixtures of four estrogenic chemicals in recombinant yeast expressing human estrogen receptor.J Vet Sci,2002,3(1):1-5
23Darbre PD,Aljarrah A,Miller WR,et al.Concentration of parabens in human breast tumours.J Appl Toxicol,2004,24:5-13
基本信息:
中图分类号:R96
引用信息:
[1]葛均辉,常兵.对羟基苯甲酸酯类物质的雌激素活性[J].卫生研究,2006(05):650-652.
基金信息:
国家自然科学基金资助项目(No.30150003); 国家科技部社会公益研究项目(No.2001DIB0059)
2006-09-30
2006-09-30