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目的调查舟山群岛居民碘营养状况、甲状腺癌患病情况及致甲状腺癌的相关影响因素。方法以整群阻随机抽样法对舟山群岛城镇居民、农民、岱山盐民、嵊泗渔民及普陀山僧侣进行流行病学问卷调查、甲状腺B超检查、甲状腺功能和尿碘测定,对甲状腺癌疑似病人行术后病理切片诊断。结果舟山群岛城镇居民、农民、岱山盐民、嵊泗渔民及普陀山僧侣的尿碘中位数(MUI)为分别为320.7、188.9、122.2、193.6和271.7μg/L,甲状腺癌累积患病率分别为215/10万(3/1 389)、398/10万(2/502)、407/10万(3/737)、829/10万(3/362)和340/10万(1/294);年龄、血清人促甲状腺激素(hTSH)是预测甲状腺癌的独立危险因素(P<0.05)。结论舟山群岛居民碘营养充足,居民甲状腺癌累积患病率较高,血清hTSH检测可预测甲状腺癌患病风险。
Abstract：Objective To investigate the nutritional status of iodine and the prevalence of thyroid carcinoma of residents in Zhoushan Archipelago,and to explore the related factors influencing the prevalence of thyroid carcinoma.Methods The residents in Zhoushan Archipelago were selected by cluster random sampling.The subjects were surveyed by questionnaire,their thyroids were examined by B-ultrasonography,the thyroid function and the levels of urine iodine were analyzed.Pathological diagnosis was conducted to the patients suspected of thyroid carcinoma.Results The median levels of urine iodine in urban residents,famers,salt-makers,fishermen from Zhoushan and buddhists from Putuoshan were 320.7,188.9,122.2,193.6 and 271.7μg/L respectively,while the prevalence rates of thyroid carcinoma were 215/100 000,398/100 000 0,407/100 000,829/100 000,340/100 000,respectively;The age or a higher level of hTSH of a person were risk factors for suffering from thyroid carcinoma.Conclusion The iodine intake of residents in ZhouShan Archipelago is adequate and the prevalence rate of thyroid carcinoma is high.Serum hTSH could be used as a predictor for the risk of thyroid carcinoma.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2012.01.018
中图分类号:R151.4;R736.1
引用信息:
[1]竺王玉,刘晓光,胡晓斐,等.舟山群岛居民碘营养状况及甲状腺癌现患调查[J].卫生研究,2012,41(01):79-82.DOI:10.19813/j.cnki.weishengyanjiu.2012.01.018.
基金信息:
国家星火计划项目(No.2008GA700174); 浙江省科技厅面上项目(No.2008C33043)
2012-01-30
2012-01-30