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分析肠道微生物与肥胖干预效果,探讨不同饮食干预下肠道微生物群的基线组成[微生物基因丰富度/多样性,肠型(细菌比例)及指示菌(细菌类群)]在肥胖干预中对机体代谢的预测作用。(1)成年肥胖人群肠道微生物种类多、基因计数较高(>480 000),高纤维和限能量膳食干预后,肠道菌群组成稳定,肠道益生菌丰度增高,有助于胰岛素抵抗、血脂异常和慢性炎症缓解;(2)肠道菌群中普雷沃氏菌/拟杆菌(P/B)较高的成年肥胖个体,高纤维和限能量膳食干预后,减重效果显著,1年内体重保持稳定;(3)嗜粘蛋白阿克曼菌(Akkermansia muciniphila)等特定菌属的丰度可以作为血糖、血脂、体脂等健康状况的预测指示菌。肠道微生物群作为治疗肥胖的技术手段具有广阔的应用前景,但这一领域的研究仍然具有挑战性,需要更大规模的人群研究,直到个性化营养切实实现并可转化为临床实践。
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基本信息:
DOI:10.19813/j.cnki.weishengyanjiu.2023.04.025
中图分类号:R589.2
引用信息:
[1]王丽媛,李岩,毛宏梅,等.肠道微生物在肥胖干预中的作用[J].卫生研究,2023,52(04):666-672.DOI:10.19813/j.cnki.weishengyanjiu.2023.04.025.
基金信息:
国家重点研发计划(No.2020YFC2006301)
2023-07-18
2023-07-18