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烷基酚类化合物 (alkylphenolcompounds,APs)因其长期的广泛应用与在环境中的大量滞留 ,已成为最常见的环境污染物之一 ,与之相关的环境内分泌干扰效应已越来越成为关注的热点和亟待研究与解决的问题。本文拟对APs及其相关化合物的生殖内分泌干扰效应和作用机制做初步论述。
Abstract：Alkylphenol compounds (APs) is one of most common environmental pollutants due to wide use and abroad existence in environment. There has been increasing concern about its impact to the endocrine system that need to be investigated. In this paper, the toxic effect and mechanism of APs on reproduction and development was reviewed.
1 ChauNagaoT ,WadaK ,MarumoH ,etalReproductiveeffectsofnonylphenolinratsaftergavageadministration:atwo generationstudyReprodToxicol,2001,15:293315
2 LawsSC ,CareySA ,FerrellJM ,etalEstrogenicactivityofoctylphenol,nonylphenol,bisphenolAandmethoxychlorinratsToxicolSci,2000,54(1):154167
3 HarazonoA ,EmaM Effectsof4 tert octylphenoloninitiationandmaintenanceofpregnancyfollowingoraladministrationduringearlypregnancyinratsToxicolLett,2001,199(1):7984
4 HowdeshellKL ,HotchkissAK ,ThayerKA ,etal.ExposuretobisphenolAadvancespuberty.Nature,1999,401:763764
5 TakaoT ,NanamiyaW ,NaganoI,etal.ExposurewiththeenvironmentalestrogenbisphenolAdisruptsthemalereproductivetractinyoungmice.LifeSci,1999,65(22):23512357
6 YoshidaM ,KatsudaS ,TakenakaA ,etal.Effectsofneonatalexposuretoahigh dosep tert octylphenolonthemalereproductivetractinrats.ToxicolLett,2001,121(1):2133
7 BendsenE ,LaursenS ,OlesenC .Effectof4 octylphenolongermcellnumberinculturedhumanfetalgonads.HumReprod,2001,16(2):236243
8 GronenS ,DenslowN ,ManningS ,etal.SerumvitellogeninlevelsandreproductiveimpairmentofmaleJapaneseMedaka(Oryziaslatipes)exposedto4 tert octylphenol.EnvironHealthPerspect,1999,107(5):385390
9 KnorrS ,BraunbeckT .Declineinreproductivesuccess,sexreversal,anddevelopmentalalterationsinJapanesemedaka(Oryziaslatipes)aftercontinuousexposuretooctylphenol.EcotoxicolEnvironSaf,2002,51(3):187196
10 WeberLP ,KiparissisY ,HwangGS ,etal.Increasedcellularapoptosisafterchronicaqueousexposuretononylphenolandquercetininadultmedaka(Oryziaslatipes).CompBiochemPhysiol,2002,131:5159
11 DielP ,OlffS ,SchmidtS ,etal.EffectsoftheenvironmentalestrogensbisphenolA ,o,p′DDT ,p tert octylphenolandcoumestrolonapoptosisinduction,cellproliferationandtheexpressionofestrogensensitivemolecularparametersinthehumanbreastcancercelllineMCF 7.SteroidBiochemMolBiol,2002,80(1):6170
12 LongXH ,SteinmetzR ,BerrJonathanN ,etal.StraindifferencesinvaginalresponsestothexenoextrogensBisphenolA .EnvironHealthPerspect,2000,108(3):243247
13 PapaconstantinouAD ,UmbreitTH ,FisherBR ,etal.BisphenolA inducedincreaseinuterineweightandalterationsinuterinemorphologyinovariectomizedB6C3F1mice:roleoftheestrogenreceptor.ToxicolSci,2000,56(2):332339
14 KhuranaS ,RanmalS ,BenJN .Exposureofnewbornmaleandfemaleratstoenvironmentalestrogens:delayedandsustainedhyperprolactinemiaandalterationsinestrogenreceptorexpression.Endocrinol,2000,141:45124517
15 RoutledgeEJ,SumpterJP .Structuralfeaturesofalkylphenolicchemicalsassociatedwithestrogenicactivity.JBiolChem,1997,272:32803288
16 ParisF ,BalaguerP ,TerouanneB ,etal.Phenylphenols,biphenols,bisphenolAand4 tert octylphenolexhibitαandβestrogenactivitiesandantiandrogenactivityinreportercelllines.MolCellEndocrinol,2002,193:4349
17 SohoniP ,SumpterJP .Severalenvironmentaloestrogensarealsoanti androgens.Endocrinol,1998,158:327339
18 GaidoKW ,ManessSC ,McDonnellDP ,etal.Interactionofmethoxychlorandrelatedcompoundswithestrogenreceptorαandβ,andandrogenreceptor:structure activitystudies.MolPharmacol,2000,58:852858
19 NikulaH ,TalonpoikaT ,KalevaM ,etal.InhibitionofhCGstimulatedsteroidogenesisinmouseLeydigtumorcellsbyBisphenolAandoctylphenols.ToxicolApplPharmacol,1999,157(3):166173
20 KlotzDM ,LadlieBL ,VonierPM ,etal.o,p′DDTanditsmetabolitesinhibitprogesterone dependentresponsesinyeastandhumancells.MolCellEndocrinol,1997,129(1):6371
21 MuronoEP ,DerkRC ,deLeonJH .Differentialeffectsofoctylphenol,17beta estradiol,endosulfan,orbisphenolAonthesteroidogeniccompetenceofculturedadultratLeydigcells.ReprodToxicol,2001,15(5):551560
22 MajdicG ,SharpeRM ,O′ShaughnessyPJ,etal.ExpressionofcytochromeP45017alpha hydroxylaseC1720lyaseinthefetalrattestisisreducedbymaternalexposuretoexogenousestrogens.Endocrinol,1996,137(3):106370
23 HughesPJ,MclellanH ,LowesDA ,etal.EstrogenicalkylphenolsinducescelldeathbyinhibitingtestisendoplasmicreticulumCa(2+)pumps.BiochemBiophysResCommun,2000,277(3):568574
24 TsutsuiT ,TarmuraY ,SuzukiA ,etal.Mammaliancelltransformationandaneuploidyinducedbyfivebisphenols.IntJCancer,2000,86(2):151154
25 OchiT .Inductionofmultiple
基本信息:
中图分类号:R114
引用信息:
[1]卞倩.烷基酚类物质的生殖发育毒效应及其作用机制[J].卫生研究,2004(03):357-360.
基金信息:
国家基础研究重大项目前期研究专向基金 (No.2 0 0 1CCA0 4 90 0 )
2004-05-20
2004-05-20