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骨桥蛋白(osteopontin, OPN)是一种具有生物活性的多功能蛋白,存在于大多数组织和体液中,在母乳中浓度最高。酶联免疫吸附测定结果显示不同哺乳期、地区母乳OPN的浓度有所差异。人和牛的OPN氨基酸序列相似,牛乳与母乳OPN的功能特征也相似。目前已建立提取并纯化母乳OPN的离子交换法,这有助于进一步了解母乳OPN的功能作用机制。母乳OPN通过不同机制影响婴儿的免疫功能、新生儿的肠道发育以及脑发育。
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基本信息:
DOI:10.19813/j.cnki.weishengyanjiu.2021.04.024
中图分类号:R151.2
引用信息:
[1]周杨,江如蓝,杨振宇.母乳骨桥蛋白研究进展[J].卫生研究,2021,50(04):676-680.DOI:10.19813/j.cnki.weishengyanjiu.2021.04.024.
基金信息:
北京市自然科学基金-三元联合资助项目(No.S160002)
2020-06-09
2020
2020-06-18
2020-06-29
2020
1
2021-07-19
2021-07-19