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尿、发、指(趾)甲中砷水平可以反应短期砷接触内剂量,可作为人体内灵敏有效的砷暴露标志物。长期慢性砷接触可以诱发皮肤色素代谢异常和掌跖角化等典型的皮肤病变,尿中MMA(V)可认为是暴露的生物有效剂量。活性氧和抗氧化能力、炎性分子基因表达、外周血淋巴细胞微核和姊妹染色单体互换和染色体畸变是无机砷摄入的早期生物效应标志物。砷易感性标志物包括DNA修复酶、氧化和抗氧化酶、氧化应激相关酶以及异物代谢酶基因组多态性。砷对健康的危害是由于基因组不稳定性和氧化应激等毒理机制而导致的基因-基因、基因-环境交互作用的慢性复杂的渐进性损害。
Abstract：A series of molecular environmental epidemiological studies have been carried out to elucidate biomarkers of exposure,effect,and susceptibility for arsenic-related health hazards in Taiwan area in China.Arsenic levels in urine,hair,and nail could be biomarkers for short-term internal dose,skin hyperpigmentation and palmoplantar hyperkeratosis could be biomarkers for long-term(many years)internal dose,and percentage of monomethylarsonic acid in total metabolites of inorganic arsenic in urine could be considered as an exposure marker for biologically effective dose.The biomarkers of early biological effects of ingested inorganic arsenic could include blood levels of reactive oxidants and anti-oxidant capacity,genetic expression of inflammatory molecules,as well as cytogenetic changes including sister chromatid exchange,micronuclei,and chromosome aberrations of peripheral lymphocytes.Biomarkers of susceptibility to arsenic-induced health hazards could include genetic polymorphisms of enzymes involved in xenobiotic metabolism,DNA repair,and oxidative stress,as well as serum level of carotenoids.Gene-gene and gene-environment interactions could be involved in arsenic-induced health hazards through toxicological mechanisms including genomic instability and oxidative stress.
1IARC.IARC monographs on the evaluation of the carcinogenic risk to humans[R].Lyon:IARC,2004,84:39-267.
2SMEDLEYP L,KINNIBURGHD G.Areviewof the source,behaviourand distribution of arsenic in natural water[J].Appl Geochem,2002,17:517-568.
3刘开泰.我国控制地方性砷中毒面临的机遇与挑战[J].中国地方病学杂志,2007,26(1):4-5.
4BUNDSCHUHJ,FARIAS B,MARTINR,et al.Groundwater arsenic in the Chaco-Pampean Plain,Argentina:case study from Robles county,Santiago del Estero Province[J].Applied Geochemistry,2004,19:231.
5NORDSTROMD K.Worldwide occurrences of arsenic in ground water[J].Science,2002,296:2142-2145.
6KLATSKY A L.RE:arsenic exposure and cardiovascular disease:a systematic reviewof the epidemiologic evidence[J].AmJ Epidemiol,2006,164(2):194-195.
7WANG C H,JENGJ S,YIP P K,et al.Biological gradient between long-termarsenic exposure and carotid atherosclerosis[J].Circulation,2002,105(15):1804-1809.
8CHEN C J,HSU L I,WANG C H,et al.Biomarkers of exposure,effect,andsusceptibility of arsenic-induced health hazardsin Taiwan[J].Toxicol Appl Pharmacol,2005,206(2):198-206.
9CHIOU H Y,HSUEH Y M,HSIEHL L,et al.Arsenic methylation capacity,body retention,and null genotypes of glutathione S-transferase M1and T1among current arsenic-exposedresidentsin Taiwan[J].Mutat Res,1997,386(3):197-207.
10HSUEHY M,HUANG Y L,HUANG C C,et al.Urinary levels of inorganic and organic arsenic metabolites amongresidentsinanarseniasis-hyperendemic area in Taiwan[J].J Toxicol Environ Health A,1998,54(6):431-444.
11MANDAL BK,OGRA Y,ANZAI K,et al.Speciation of arsenic in biological samples[J].Toxicol Appl Pharmacol,2004,198(3):307.
12National Resaerch Council.Arsenic in drinking water[M].Washington DC:National Academy Press,2000:101-130.
13HSUEHY M,CHIOU HY,HUANG YL,et al.Serumbeta-carotene level,arsenic methylation capability,and incidence of skin cancer[J].Cancer Epidemiol Biomarkers Prev,1997,6(8):589-596.
14YUR C,HSUKH,CHENCJ,et al.Arsenic methylation capacity and skin cancer[J].Cancer Epidemiol Biomarkers Prev,2000,9(11):1259-1262.
15CHENYC,GUO Y L,SU HJ,et al.Arsenic methylation and skin cancer riskin southwestern Taiwan[J].J Occup Environ Med,2003,45(3):241-248.
16CHENYC,SUHJ,GUO YL,et al.Arsenic methylation and bladder cancer riskin Taiwan[J].Cancer Causes Control,2003,14(4):303.
17HSUEHY M,KO YF,HUANG Y K,et al.Determinants of inorganic arsenic methylation capability among residents of the Lanyang Basin,Taiwan:arsenic and selenium exposure and alcohol consumption[J].Toxicol Lett,2003,137(1-2):49-63.
18HUANG Y K,TSENG C H,HUANG Y L,et al.Arsenic methylation capability and hypertension risk in subjects living in arseniasis-hyperendemic areasinsouthwestern Taiwan[J].Toxicol Appl Pharmacol,2007,218(2):135-142.
19WU M M,CHIOU H Y,HSUEH Y M,et al.Effect of plasma homocysteine level and urinary monomethylarsonic acid on the risk ofarsenic-associated carotid atherosclerosis[J].Toxicol Appl Pharmacol,2006,216(1):168-175.
20TSENGC H.Arsenic methylation,urinary arsenic metabolites and human diseases:current perspective[J].J Environ Sci Health C Environ Carcinog Ecotoxicol Rev,2007,25(1):1-22.
21WU MM,CHIOUHY,WANGT W,et al.Associationof blood arsenic levels withincreased reactive oxidants and decreased antioxidant capacity in a human population of northeastern Taiwan[J].Environ Health Perspect,2001,109(10):1011-1017.
22WU MM,CHIOUHY,HOI C,et al.Gene expression of inflammatory moleculesin circulatinglymphocytesfromarsenic-exposed human subjects[J].Environ Health Perspect,2003,111(11):1429-1438.
23MARTINEZ V,CREUS A,VENEGAS W,et al.Evaluation of micronucleusinductionin a Chilean population environmentally exposedto arsenic[J].Mutat Res,2004,564(1):65-74.
24BASU A,MAHATA J,ROY A K,et al.Enhanced frequency of micronuclei in individuals exposed to arsenic through drinking water in West Bengal,India[J].Mutat Res,2002,516(1-2):29-40.
25MAHATAJ,BASU A.Chromosomal aberrations and sister chromatid exchanges in individuals exposed to arsenic through drinking water in West Bengal,India[J].Mutat Res,2003,534(1-2):133-143.
26MAHATA J.Chromosomal aberrations in arsenic-exposed human populations:a reviewwith special reference to a comprehensive study in West Bengal,India[J].Cytogenet Genome Res,2004,104(1-4):359-364.
27AHMADS A,KHATUN F,SAYED MH,et al.Electrocardiographic abnormalities among arsenic-exposed persons through groundwater in Bangladesh[J].J Health Popul Nutr,2006,24(2):221-227.
28HSUC H,YANGS A,WANGJ Y,et al.Mutational spectrumof p53gene in arsenic-related skin cancers fromthe blackfoot disease endemic area of Taiwan[J].Br J Cancer,1999,80(7):1080-1086.
29TSENG YS,TZENGC C,HUANGC Y,et al.Aurora-Aoverexpression associates with Ha-ras codon-12mutation and blackfoot disease endemic area in bladder cancer[J].Cancer Lett,2006,241(1):93-101.
30HSUEHY M,WU WL,HUANG YL,et al.Lowserumcarotene level andincreased risk of ischemic heart disease related to long-termarsenic exposure[J].Atherosclerosis,1998,141(2):249-257.
31CHIOU H Y,WANG I H.Arsenic exposure,null genotypes of glutathione S-transferase M1,T1and P1,and risk of carotid atherosclerosis among residents in Lanyang Bsin of Taiwan[C]//CHAPPELL W R,ABERNATHY C O,CALDERON R L.Arsenic Exposure and Health Effects.Amsterdam:Elsevier Science BV,2001:207-220.
32WANG Y H,WU MM,HONG C T,et al.Effects of arsenic exposure and genetic polymorphisms of p53,glutathione S-transferase M1,T1,and P1onthe risk of carotid atherosclerosis in Taiwan[J].Atherosclerosis,2006,141(2):300-303.
33HSUEHY M,LIN P,CHEN H W,et al.Genetic polymorphisms of oxidative and antioxidant enzymes and arsenic-related hypertension[J].J Toxicol Environ Health A,2005,68(17-18):1471-1484.
基本信息:
中图分类号:R114
引用信息:
[1]安艳,银丽娟,王三祥,等.砷致健康危害生物标志物研究进展[J].卫生研究,2008(02):237-241.
基金信息:
国家自然科学基金资助项目(No.30540018); 教育部留学回国人员科研启动基金(2006); 人事部留学回国人员科技活动择优资助项目(2006); 山东省优秀中青年科学家科研奖励基金(No.2006BS03067)
2008-03-30
2008-03-30