卫生研究

为探讨长期摄入酒精对大鼠血糖、胰岛素及糖耐量 (GTT)的影响 ,以不同浓度的酒精溶液对大鼠灌胃 60天。结果显示 :大鼠摄入 3 0 %、5 0 %酒精 60天后 ,与对照组比较 ,空腹血糖明显升高 ,1h、2h、3h糖耐量异常 (P <0 0 5 ) ,并且雌雄大鼠之间也存在明显差异。随着剂量的增加 ,各组血胰岛素水平逐渐降低 ,5 0 %酒精摄入组与对照组存在着明显差异 (P <0 0 5 )。结果提示 :长期饮酒可导致大鼠空腹血糖升高 ,糖耐量异常 ,提示长期饮酒有可能导致糖尿病 ,并且胰岛素水平降低可能是导致糖尿病的机制之一。

In order to study the effects of chronic alcohol intake on serum glucose, insulin and glucose tolerance test (GTT), a oral administration of alcohol solution (6ml/kg·d) in different concentration (10%, 30% and 50%) is given to rats for 60 days. The results showed that the fast serum glucose of rats in the groups orally administrated with 30% and 50% alcohol solution increases obviously in comparison with that in control group. There exist abnormalities in 1 hour, 2 hour and, 3 hour GTT ( P< 0 05) in these groups and the difference in gender in both groups is statistically significant. It is also shown that the level of serum insulin of rats decreased along with the increase of alcohol dosage and is significantly lower in the group of rats administered 50% alcohol solution than that in the normal control group ( P< 0 05). These results demonstrated that chronic alcohol intake causes the increases of fast serum glucose and abnormality of glucose tolerance test (GTT), and likely, the final abnormality of glucose metabolism in which the decrease of insulin secretion might be one of the contributing factors to the pathogenesis.