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目的探讨糖尿病家族史与腰臀比异常在2型糖尿病中的交互作用。方法采用病例-对照研究,以604例2型糖尿病新发病例为病例组,以同社区与病例组无血缘关系的3985例血糖正常者为对照组。用相加模型分析糖尿病家族史与腰臀比异常对2型糖尿病的交互作用。结果用多因素logistic回归调整混杂因素后,协同效应指数为5.63,归因交互效应为1.49,归因交互效应百分比为52.9%。结论糖尿病家族史与腰臀比异常对2型糖尿病的发病有协同作用。
Abstract：Objective To explore the synergistic effect between diabetes family history and abnormal waist-to-hip ratio(WHR) on the incidence of type 2 diabetes.Methods Population-based case-control study was conducted.The interaction between diabetes family history and abnormal WHR was analysed by an additive model.Results After adjusting confounding factors by multiple logistic regression analysis,the synergy index was 5.63,the attributable risk was 1.49,and the attributable interaction percent was 52.9%.Conclusion There was a synergistic effect between diabetes family history and abnormal WHR on the incidence of type 2 diabetes.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2012.02.034
中图分类号:R587.1
引用信息:
[1]刘丽,逄增昌,汪韶洁,等.糖尿病家族史与腰臀比异常对2型糖尿病的协同作用[J].卫生研究,2012,41(02):308-310.DOI:10.19813/j.cnki.weishengyanjiu.2012.02.034.
基金信息:
世界糖尿病基金会项目(No.WDF07-308)
2012-03-30
2012-03-30