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目的 探讨银川市青少年血清鸢尾素水平与糖脂代谢的关系。方法 于2017—2020年采用方便抽样与分层整群随机抽样相结合的方法抽取银川市1219名12～18岁的青少年作为研究对象，测量身高和体重。检测空腹血糖(fasting plasma glucose, FPG)、总胆固醇(totalcholesterol, TC)、甘油三酯(triglyceride, TG)、低密度脂蛋白胆固醇(low-density lipoprotein cholesterol, LDL-C)和高密度脂蛋白胆固醇(high-density lipoprotein cholesterol, HDL-C)。通过酶联免疫吸附试验(enzyme linked immunosorbent assay, ELISA)进行血清鸢尾素水平的测定。采用二分类Logistic回归分析鸢尾素与糖脂代谢异常的关联强度。结果 鸢尾素水平最高三分位数受试者的FPG、TC、HDL-C和LDL-C水平显著低于鸢尾素水平最低三分位数的受试者(F值分别为5.13、3.15、3.07和5.01,P<0.05)。高血糖组(t=2.87,P<0.01)、高TC血症组(t=2.36,P=0.02)以及高LDL-C血症组(t=2.34,P=0.02)的血清鸢尾素水平显著低于正常血糖组、正常TC组和正常LDL-C组，而低HDL-C血症组(t=-2.57,P=0.01)的鸢尾素水平高于正常HDL-C组。鸢尾素最高三分位数受试者发生高血糖、高TC血症、高LDL-C血症的风险是最低三分位数参与者的0.51倍(95%CI 0.29～0.87)、0.49倍(95%CI 0.27～0.89)和0.50倍(95%CI 0.25～0.99)。结论 低水平鸢尾素与青少年高血糖、高TC血症以及高LDL-C血症的发生有关。
Abstract：OBJECTIVE To explore the relationship between serum irisin levels and glucose and lipid metabolism among adolescents in Yinchuan City.METHODS From 2017 to 2020, a conbination of convenient sampling and stratified cluster random sampling method were used to select 1219 adolescents aged 12 to 18 years old in Yinchuan City as research subjects. The height and weight were measured using the height and sitting height meter and the bioelectrical impedance analyzer. Blood indicators such as fasting plasma glucose(FPG), totalcholesterol(TC), triglyceride(TG), low-density lipoprotein cholesterol(LDL-C) and high-density lipoprotein cholesterol(HDL-C) were measured using fully automatic biochemical analyzer. Serum irisin levels were measured by enzyme-linked immunosorbent assay(ELISA). Binary logistic regression was used to analyze the correlation between irisin and abnormal glucose and lipid metabolism.RESULTS The FPG, TC, HDL-C and LDL-C levels of subjects in the highest tertile of irisin levels were significantly lower than those of subjects in the lowest tertile of irisin levels(F values were 5.13, 3.15, 3.07 and 5.01, P<0.05), and the differences were statistically significant(all P<0.05). The serum irisin levels in the hyperglycemia group(t=2.87, P<0.01), hypercholesterolemia group(t=2.36, P=0.02) and hyperLDL-Cemia group(t=2.34, P=0.02) were significantly lower than those in the normoglycemia group, normal TC group and normal LDL-C group. Meanwhile, the irisin level in the low HDL-Cemia group(t=-2.57, P=0.01) was significantly higher than that in the normal HDL-C group, and the differences were statistically significant(P<0.05). Participants in the highest tertile of irisin had 0.51, 0.49 and 0.50 times the risk of hyperglycemia(OR=0.51, 95%CI 0.29-0.87), hypercholesterolemia(OR=0.49, 95%CI 0.27-0.89) and hyperLDL-cemia(OR=0.50, 95%CI 0.25-0.99) compared with those in the lowest tertile.CONCLUSION Low levels of irisin are associated with the occurrence of hyperglycemia, hypercholesterolemia, and hyperLDL-Cemia in adolescents.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2024.04.009
中图分类号:R725.8;R181.3
引用信息:
[1]佟玲玲,田梅,马晓燕,等.2017—2020年银川市青少年血清鸢尾素水平与糖脂代谢的关系[J].卫生研究,2024,53(04):576-583.DOI:10.19813/j.cnki.weishengyanjiu.2024.04.009.
基金信息:
国家自然科学基金(No.82160641); 宁夏自然科学基金(No.2023AAC03180)
2024-07-26
2024-07-26