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近年来研究显示叶酸代谢酶的基因多态性通过影响体内叶酸水平和循环代偿,直接或间接参与心脑血管疾病的发生和发展。本综述旨在通过系统的文献检索,了解基因多态性对叶酸干预心脑血管疾病的影响。目前的研究集中于MTHFR C677T基因,叶酸干预心脑血管疾病需要考虑MTHFR C677T基因多态性所带来的影响,对于心脑血管疾病高危人群推荐补充叶酸。对于CC型受试者,根据个体情况推荐每日补充叶酸0.4~0.8 mg;对于TT基因型受试者,推荐每日补充叶酸至少0.8 mg,可根据个体情况酌情增加补充剂量。根据个人遗传背景和营养状况为心脑血管疾病患者制定精准的叶酸干预措施,有助于降低高Hcy血症引起心脑血管并发症的风险。
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基本信息:
DOI:10.19813/j.cnki.weishengyanjiu.2023.04.023
中图分类号:R54;R743
引用信息:
[1]石丽丽,李岩,毛宏梅,等.基因多态性在叶酸干预心脑血管疾病中的作用[J].卫生研究,2023,52(04):648-656.DOI:10.19813/j.cnki.weishengyanjiu.2023.04.023.
基金信息:
国家重点研发计划(No.2020YFC2006301)
2023-07-18
2023-07-18