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目的探讨低剂量二巯基丁二酸(DMSA)和营养素(钙、锌、维生素C、维生素B1)联合应用对儿童铅中毒干预效果。方法选择血铅水平≥100μg/L,未进行过药物和非药物驱铅治疗的儿童共91名,随机分为对照组(15人)、营养素干预组(营养素组,33人)和DMSA与营养素联合干预组(联合组,43人)。对照组不施加干预因素;营养素组给予钙250mg/d,锌10mg/d,维生素C200mg/d,维生素B150mg/d;联合组给予二巯基丁二酸0.25g/次、钙250mg/d,锌10mg/d,维生素C200mg/d,维生素B150mg/d。连续干预4周,分别于干预结束时及结束后第8周测血铅值。结果干预结束时,营养素组、联合组儿童血铅水平均明显低于对照组(P<0.05),分别有8名和24名儿童血铅值降至正常水平(100μg/L以下)。干预结束至第8周时,营养素组儿童血铅水平下降趋势明显变缓,联合组则持续下降,血铅水平降至正常者分别达到12名和31名。结论低剂量DMSA与营养素联合应用治疗儿童铅中毒具有明显的效果。
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基本信息:
中图分类号:R725.9
引用信息:
[1]于飞,金亚平,智绪平,等.低剂量二巯基丁二酸与营养素联合应用对铅中毒儿童的干预研究[J].卫生研究,2007(05):608-609.
基金信息:
辽宁省自然科学基金资助(No.20032063)
2007-09-30
2007-09-30