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目的 分析1990—2019年中国室外臭氧暴露致慢性阻塞性肺部疾病(chronic obstructive pulmonary disease, COPD)的疾病负担。方法 基于2019年全球疾病负担研究(global burden of disease study, GBD)数据，分析1990—2019年中国室外臭氧暴露致COPD死亡例数、死亡率、伤残调整寿命年(disability adjusted life years, DALY)以及DALY率变化情况，并通过世界标准人口的年龄结构对死亡率和DALY率进行标化，与全球及各级社会人口学指数(socio-demographic index, SDI)国家平均水平进行比较。结果 2019年中国15岁及以上人群中，6.99%的COPD死亡是由室外臭氧暴露导致，归因死亡人数(9.33万例)占同期全球水平(36.52万例)的25.54%,其中男性5.34万例，女性3.98万例，归因DALY(137.29万人年)占同期全球水平(621.01万人年)的22.11%;标化死亡率和DALY率较中等SDI国家分别高出25.61%和10.92%,较高SDI国家分别高出373.88%和284.63%。1990—2019年，随年龄增长，人群归因分值(population attributable fraction, PAF)、归因死亡率和DALY率均呈上升趋势，≥70岁年龄组达高峰，且男性均明显高于女性。结论 中国归因于室外臭氧暴露致COPD的疾病负担沉重，且存在性别和年龄组差异。
Abstract：OBJECTIVE To analyze the disease burden of chronic obstructive pulmonar ydisease caused by outdoor ozone exposure in China from 1990 to 2019. METHODS Based on the global burden of disease study data in 1990-2019, the number of chronic obstructive pulmonary disease(COPD) deaths, mortality, disability-adjusted life years(DALY) and DALY rates caused by outdoor ozone exposure in China from 1990 to 2019 were analyzed, and the mortality and DALY rates were standardized through the age structure of the world standard population, and compared with the national average of global and all levels of social demographic index(SDI). RESULTS In 2019, 6.99% of COPD deaths among people aged 15 and over in China were caused by outdoor ozone exposure, and the number of attributable deaths(93 300) accounted for 25.54% of the global level(365 200) in the same period, including 53 400 males and 39 800 females, and attributable DALY(1.3729 million person-years) accounted for 22.11% of the global level(6.2101 million person-years) in the same period. The standardized mortality rate and DALY rate were 25.61% and 10.92% higher than those of medium SDI countries, and 373.88% and 284.63% higher than those of high SDI countries, respectively. From 1990 to 2019, the population attribution score(population attributable fraction, PAF), attributable mortality and DALY rate increased with the increase of age, and reached the peak in the age group ≥70 years old, and the scores of males were significantly higher than those of females. CONCLUSION China is attributed to the heavy disease burden of COPD caused by outdoor ozone exposure, and there are differences in gender and age groups.
[1] 中华医学会呼吸病学分会慢性阻塞性肺疾病学组，中国医师协会呼吸医师分会慢性阻塞性肺疾病工作委员会.慢性阻塞性肺疾病诊治指南(2021年修订版)[J].中华结核和呼吸杂志，2021,44(3):170-205.
[2] GBD 2019 Diseases and Injuries Collaborators.Global burden of 369 diseases and injuries in 204 countries and territories,1990-2019:a systematic analysis for the Global Burden of Disease Study 2019[J].Lancet,2020,396(10258):1204-1222.
[3] GBD 2019 Risk Factors Collaborators.Global burden of 87 risk factors in 204 countries and territories,1990-2019:a systematic analysis for the Global Burden of Disease Study 2019[J].Lancet,2020,396(10258):1223-1249.
[4] GBD 2019 Demographics Collaborators.Global age-sex-specific fertility,mortality,healthy life expectancy (HALE),and population estimates in 204 countries and territories,1950-2019:a comprehensive demographic analysis for the Global Burden of Disease Study 2019[J].Lancet,2020,396(10258):1160-1203.
[5] 中华人民共和国环境保护部.关于发布《环境空气质量标准》(GB 3095—1996)修改单的通知单.(2000-01-06)[2021-09-10].http://www.mee.gov.cn/gkml/zj/wj/200910/t20091022_171965.htm?keywords.
[6] MUMBY S,CHUNG K F,ADCOCK I M.Transcriptional effects of ozone and impact on airway inflammation[J].Front Immunol,2019,10:1610.
[7] KLEINMAN M T,PHALEN R F.Toxicological interactions in the respiratory system after inhalation of ozone and sulfuric acid aerosol mixtures[J].Inhal Toxicol,2006,18(4):295-303.
[8] WICHER S A,LAWSON K L,JACOBY D B,et al.Ozone-induced eosinophil recruitment to airways is altered by antigen sensitization and tumor necrosis factor-á blockade[J].Physiol Rep,2017,5(24):e13538.
[9] TURNER M C,JERRETT M,POPE C A 3rd,et al.Long-term ozone exposure and mortality in a large prospective study[J].Am J Respir Crit Care Med,2016,193(10):1134-1142.
[10] WANG Y,WILD O,CHEN X,et al.Health impacts of long-term ozone exposure in China over 2013—2017[J].Environ Int,2020,144:106030.
[11] CONIBEAR L,BUTT E W,KNOTE C,et al.Current and future disease burden from ambient ozone exposure in India[J].Geohealth,2018,2(11):334-355.
[12] YIN P,CHEN R,WANG L,et al.Ambient ozone pollution and daily mortality:a nationwide study in 272 Chinese Cities[J].Environ Health Perspect,2017,125(11):117006.
[13] 陶凤然，樊娜，蒋云雯，等.1997—2017年中国人群慢性阻塞性肺病疾病负担趋势分析[J].中国慢性病预防与控制，2020,28(1):3-9.
[14] 殷鹏，王黎君，刘世炜，等.1990年与2010年中国15岁以上人群慢性阻塞性肺疾病的疾病负担分析[J].中华预防医学杂志，2015,49(4):334-338.
[15] 崔娟，殷鹏，王黎君，等.1990年与2013年中国大气臭氧污染导致慢性阻塞性肺疾病的疾病负担分析[J].中华预防医学杂志，2016,50(5):391-396.
[16] 黄菲菲，秦继山.中老年慢性阻塞性肺疾病临床特征与病情进展的相关性[J].实用临床医药杂志，2021,25(1):45-49.
[17] 孟晓艳，宫正宇，叶春霞，等.2013—2016年74城市臭氧浓度变化特征[J].中国环境监测，2017,33(5):101-108.
[18] 朱欢欢.环境空气臭氧暴露的慢性健康效应研究[D].石家庄：河北科技大学，2020.
[19] 栗泽苑，杨雷峰，华道柱，等.2013—2018年中国近地面臭氧浓度空间分布特征及其与气象因子的关系[J].环境科学研究，2021,34(9):2094-2104.
[20] 王鑫龙，赵文吉，李令军，等.中国臭氧时空分布特征及与社会经济因素影响分析[J].地球与环境，2020,48(1):66-75.
基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2022.02.012
中图分类号:R563.9
引用信息:
[1]袁凯英,李望晨,屈香,等.1990—2019年中国室外臭氧暴露致慢性阻塞性肺部疾病的疾病负担分析[J].卫生研究,2022,51(02):246-250.DOI:10.19813/j.cnki.weishengyanjiu.2022.02.012.
基金信息:
国家自然科学基金面上项目(No.81872721); 国家重点研发计划(No.2017YFC1310902)
2022-03-26
2022-03-26