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目的 了解内蒙古自治区蒙古族成年人群高尿酸血症(hyperuricemia, HUA)的流行病学特点及相关因素。方法 采用多阶段分层与人口比例的整群随机抽样方法，于2018年8月至2020年8月抽取内蒙古自治区2219名18岁及以上的蒙古族人群，收集对象人口学资料、个人生活行为史和膳食情况，进行体格检查和血液生化检测。统计HUA患病率，采用Logistic回归分析和决策树模型进行危险因素分析。结果 蒙古族成年人群HUA患病率为19.74%,标化患病率为21.07%,男性(26.3%)高于女性(15.6%),不同身高、体重、职业、文化程度和地区的人群患病率差异有统计学意义(P<0.05)。Logistic回归分析结果显示，HUA的发生与超重肥胖(OR=2.002,95%CI 1.519～2.638)、血脂异常(OR=1.620,95%CI 1.271～2.064)、血糖异常(OR=1.563,95%CI 1.195～2.046)、猪肉(OR=1.231,95%CI 1.139～1.330)、羊肉(OR=1.287,95%CI 1.179～1.404)、禽肉(OR=1.111,95%CI 1.024～1.206)、饮酒(OR=1.145,95%CI 1.008～1.302)呈正相关。与女性(OR=0.641,95%CI 0.498～0.827)、体力劳动(OR=0.629,95%CI 0.477～0.829)、豆类及其制品(OR=0.889,95%CI 0.811～0.976)、奶及奶制品的摄入量(OR=0.854,95%CI 0.785～0.921)呈负相关。决策树模型结果显示：猪肉摄入量、超重肥胖、血脂异常、羊肉摄入量、性别是影响HUA的变量。结论 2018—2020年内蒙古自治区蒙古族成年人群HUA患病率较高，且性别、职业、体质指数、血脂、血糖及部分饮食因素均与HUA有关联。
Abstract：OBJECTIVE To understand the epidemiological characteristics of hyperuricemia(HUA) in Mongolian adults in Inner Mongolia Autonomous Region, and to explore the related factors.METHODS Using multi-stage stratified and population proportional cluster random sampling investigated 2301 Mongolian population aged 18 and older living in Inner Mongolia Autonomous Region from August 2018 to August 2020. The participant general demographic data, personal life and behavior history and diet were collected, and participant physical examination and blood biochemical tests were performed. The prevalence of HUA was counted, and the risk factors were analyzed by Logistic regression analysis and decision tree model.RESULTS The prevalence rate of HUA in Mongolian adult population was 19.74%, and the standardized prevalence rate was 21.07%. Male(26.3%) was higher than female(15.6%), and there were significant differences in the prevalence rate among populations with different height, weight, occupation, education level and regions(P<0.05), Logistic regression analysis showed that the occurrence of HUA and overweight and obesity(OR=2.002, 95%CI 1.519-2.638), and dyslipidemia(OR=1.620, 95%CI 1.271-2.064), abnormal blood glucose(OR=1.563, 95%CI 1.195-2.046), pork(OR=1.231, 95%CI 1.139-1.330), mutton(OR=1.287, 95%CI 1.179-1.404), poultry meat(OR=1.111, 95%CI 1.024-1.206), alcohol drinking alcohol(OR=1.145, 95%CI 1.008-1.302) showed a positive correlation. It was negatively associated with women(OR=0.641,95%CI 0.498-0.827), manual labor(OR=0.629,95%CI 0.477-0.829), beans and their products(OR=0.889,95%CI 0.811-0.976), milk and milk intake(OR=0.854,95%CI 0.785-0.921). The result of decision tree model showed that pork intake, overweight and obesity, dyslipidemia, mutton intake and gender were the variables affecting HUA.CONCLUSION The prevalence of HUA in the Mongolian population was relatively high, and the gender, occupation, body mass index, blood lipid, blood glucose and some dietary factors were all associated with HUA.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2022.06.014
中图分类号:R589.7
引用信息:
[1]董嘉慧,庞慧,赵灵燕.2018—2020年内蒙古蒙古族成年人高尿酸血症现状及相关因素[J].卫生研究,2022,51(06):940-946.DOI:10.19813/j.cnki.weishengyanjiu.2022.06.014.
基金信息:
国家自然科学基金(No.81660564); 内蒙古自治区自然科学基金(No.2018MS08014); 内蒙古医科大学慢性病分子流行病学创新团队(No.YKD2017KJXCTDO15);内蒙古医科大学“致远”人才计划(No.ZY0201013); 2020年度内蒙古自治区“草原英才”工程青年创新创业培养计划
2022-11-24
2022-11-24