卫生研究

目的以传统硒源亚硒酸钠为对照,探究纳米硒(Nano-Se)对小鼠学习记忆、脑组织和肝组织中两种含硒酶活性的影响。方法用两种硒源的硒分别以每只1、2、4μgSe/d的水平对小鼠进行灌胃。运用Y型迷宫试验测试小鼠的学习记忆能力;测定各组小鼠脑组织、肝脏中的谷胱甘肽过氧化物酶(GSH-Px)和脱碘酶(ID)活性。结果纳米硒(Nano-Se)三个剂量组小鼠与对照组比较,学习记忆成绩均有明显改善(P<0.01或P<0.05),脑组织和肝脏中的GSH-Px和ID活性明显升高(P<0.01或P<0.05),且均强于同剂量的亚硒酸钠组(P<0.01或P<0.05)。结论纳米硒(Nano-Se)能提高小鼠的学习记忆能力及脑和肝脏两种含硒酶活性。

Objective To investigate the effects of Nano-Selenium on learning memory capability and activity of two kinds of Se-protein in brain and liver of mice, Na_2SeO₃ as the controls. Methods The mice were administred two kinds of origin (doses of 1μgSe/d, 2μgSe/d, 4μgSe/d) Se by intra-gastric injection respectively. The learning memory ability of the mice was measured by Y-type maze test. Activities of glutathione peroxidase (GSH-Px) and iodothyronine deiodinase(ID) in brain and liver were also measured. Results In comparition with the control groups of Na_2SeO₃, learning memory abilities were improved and activities of ID and GSH-Px (P<0.01 or P<0.05) of brain and liver were increased in Nano-Se treatment groups. Conclusion Nano-Se could improve learning memory ability of mice, and enhance ID and GSH-Px activities of brain and liver in mice.