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目的 探究老年人炎症相关膳食模式与肌肉衰减症及其相关肌肉健康指标的关联。方法 该研究基于2020年中国老年人营养改善策略与应用项目，选取了内蒙古自治区巴彦淖尔市五原县、江苏省太仓市和广东省广州市越秀区三个地区65岁及以上老年人进行调查，最终纳入834名符合条件的研究对象。通过食物频率问卷收集膳食数据，采用降秩回归法提取炎症相关膳食模式，并使用亚洲肌肉衰减症工作组2019年推荐标准诊断肌肉衰减症。采用Logistic回归模型分析炎症相关膳食模式与老年人肌肉衰减症及肌肉健康相关指标的关系。结果 研究人群肌肉衰减症患病率为19.9%。炎症标志物超敏C反应蛋白和白介素-12与肌肉衰减症风险显著相关(OR值分别为1.12(95%CI 1.06～1.18)、1.08(95%CI 1.03～1.14))。炎症相关膳食模式分析显示，禽肉、杂豆类、面类、动物油等食物摄入较多，而植物油、米类、大豆类、蛋类、水果、薯类、蔬菜等食物摄入较少。在调整后的模型中，炎症相关膳食模式与肌肉衰减症发病风险无显著相关性。进一步分析发现，该模式与老年人较低肌肉质量呈显著正相关(P<0.05)。结论 该研究未发现老年人炎症相关膳食模式与肌肉衰减症发病风险的直接关联，但揭示了其与老年人肌肉质量的负向关联。
Abstract：OBJECTIVE To explore the association between inflammation-related dietary patterns and sarcopenia and its related muscle health indicators in the elderly.METHODS For this study on improving nutrition among the elderly in China, we selected Wuyuan County in Bayannur City, Inner Mongolia Autonomous Region; Taicang City in Jiangsu Province; and Yuexiu District in Guangzhou City, Guangdong Province.834 eligible subjects aged 65 and above were finally included. Dietary data were collected through the food frequency questionnaire(FFQ). Inflammation-related dietary patterns were extracted using the reduced-rank regression method, and sarcopenia was diagnosed using the Asian Working Group on Muscular Attenuation(AWGS) 2019 recommendation criteria. Logistic regression model was used to analyze the relationship between inflammation-related dietary patterns and sarcopenia and muscle health-related indicators in the elderly.RESULTS The prevalence of sarcopenia in the study population was 19.9%. The inflammatory markers hypersensitive C-reactive protein and interleukin-12 were significantly associated with the risk of sarcopenia(OR=1.12(95%CI 1.06-1.18), OR=1.08(95%CI 1.03-1.14)). Analysis of dietary patterns related to inflammation showed that poultry meat, legumes, flour, animal oil and other foods were more consumed, while vegetable oil, rice, soybeans, eggs, fruits, potatoes, vegetables and other foods were less consumed. In the adjusted model, there was no significant correlation between inflammation-related dietary patterns and the risk of sarcopenia. Further analysis found that this pattern was significantly positively correlated with lower muscle mass in the elderly(P<0.05).CONCLUSION This study did not find a direct association between inflammation-related dietary patterns and the risk of sarcopenia, but revealed a negative association with muscle mass in the elderly.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2025.06.004
中图分类号:R685
引用信息:
[1]焦天然,蒲荣畅,滕波,等.老年人炎症相关膳食模式和肌肉衰减症的关联性[J].卫生研究,2025,54(06):900-907.DOI:10.19813/j.cnki.weishengyanjiu.2025.06.004.
基金信息:
中央财政项目-合理膳食与营养健康(No.131031107000150007); 科技部四大慢病重大专项(No.2023ZD0508404)