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本研究选用健康成年的ＳＤ大鼠４２只，随机分为６组，于大鼠饮用水中加入不同剂量的氟化钠，饮４周后，维甲酸灌胃２周，诱发大鼠实验性骨质疏松症模型，实验期共６周。通过对大鼠血液和骨骼氟（Ｆ）、钙（Ｃａ）、磷（Ｐ）、羟脯氨酸（ＨＯＰ）测定以及骨组织形态学等指标的分析，结果表明：（１）氟化钠可以预防或减轻由维甲酸引起的大鼠骨质疏松症；（２）达到预防效果的最佳水氟浓度范围是１０～２０ｍｇ／Ｌ；（３）对于预防人类骨质疏松症，氟的有效剂量和时间尚需做进一步的探讨。
Abstract：Forty two rats were divided into 6 groups randomly to study the preventive effects of sodium fluoride on experimental osteoporosis.Rats drank fluoridated water containing various dosages of sodium fluoride for 4 weeks.The rats were then administered by gavage with retinoic acid for 2 weeks to induce experimental osteoporosis model,fluoridated water was given simuetaneousey,Two weeks eater the contents of fluorine,calcium,phosphorus and hydroxyproline in blood and bone were meosured and femoral histomorphology observed.(1)Sodium fluoride may prevent osteoporosis in rats induced by retinoic acid.(2) The most suitable fluorine ion concentration in fluoridated water is 10～20g/L.(3) The effective fluoride dosage and the most suitable period taking fluoride remain to be studied deeply,when fluoride is taken to prevent human osteoporosis.
1山本博司。脊椎骨粗松症压迫骨折治疗，整外Mook，1986，46：2742CharlesYCPak．Fluorideandosteoporosis．ProcSocExpBiolMed，1989，56（4）：2783SowersMFk，WallaceKB，LemkeJH，etal．Therelationshipofbonemassandfracturehistorytofluorideandcalciumintake：Astudyofthreecommunities．AmJClinNutr，1986，44：8894王虹．氟电极快速测定人血清氟．中国地方病防治杂志，1986，3（3）：1885上海市医学化验所主编。临床生化检验。上海：上海科学技术出版社，19796郑少雄、蔡文仪、邱明才，等．血尿羟脯氨酸测定的方法改进。中华医学检验杂志，1983，6（3）：1337FarleyJR，WergedalJE，BaylinkDJ，etal．Fluoridedirectlystimulatesprolirerationandalkalinephosphataseactivityofboneformingcells．Scier1ce，1983，222：3308谭见安。氟的地域分异，生态平衡与健康（综述）．国外医学医学地理分册1990
基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.1995.02.015
中图分类号:R681.02
引用信息:
[1]张建清，吴斌，袁宝珊.氟化钠对大鼠实验性骨质疏松症预防作用的研究[J].卫生研究,1995(02).DOI:10.19813/j.cnki.weishengyanjiu.1995.02.015.
1995-03-20
1995-03-20