| 111 | 2 | 23 |
| 下载次数 | 被引频次 | 阅读次数 |
目的研究大豆β-伴球蛋白对40～60岁高血脂妇女的血清甘油三酯的降低作用。方法按照保健食品评价规范选择单纯高血脂的40～60岁女性100名,随机分为3组(高剂量组:摄食大豆伴球蛋白片4.6g/d,低剂量组:摄食大豆β-伴球蛋白片2.3g/d,安慰剂组:服用酪蛋白片安慰剂10.0g/d),干预12周。分别在0、6和12周对受试者膳食、运动等情况进行问卷调查,并检测各组血脂(TG、TC、LDL-C、HDL-C)。结果大豆β-伴球蛋白干预低剂量组血清TG降低了24.96%,高剂量组降低了38.70%。结论大豆β-伴球蛋白可以显著降低40～60岁高血脂女性血清甘油三酯水平,具有显著的降低中性脂肪的作用。
Abstract：Objective Improving effects on serum triacylglyceride in women with hypertriacylglycerolemia by soybean β-conglycinin.Methods A placebo-controlled,randomized,double-blind study was conducted in 100 women aged 40-60 with TC>6.22 mmol/L(or TG>1.70mmol/L).The subjects were administered β-conglycinin 4.6g(high dose) in 8 test tablets and 2.3g(low dose) in 4 test tablets daily for the two test groups and 4 placebo tablets containing noβ-conglycinin for the control group for 12 weeks.Results Compared to the control group,serum triacylglycerol in the high dose group was significantly reduced at the 6th week(P<0.001) and the 12th week(P=0.001) of the trial.Serum triacylglycerol in the low dose group was reduced at the 6th week(P<0.001) of the trial.Conclusion Soybean β-conglycinin seemed to have a positive effect of reducing serum triglycerides and improving serum lipids in people with hyperlipidemia.
1李立明,饶克勤,孔灵芝,等.中国居民2002年营养与健康状况调查[J].中华流行病学杂志,2005,26(7):478-484.
2李淑波,徐志鑫,耿坤,等.北京市昌平区居民血脂水平与血压、年龄、性别的相关性分析[J].中国预防医学杂志,2008,9(11):987-989.
3王琼,张青云,刘娟.北京地区13336例成人空腹血脂水平分析[J].中华检验医学杂志,2007,30(5):524-528.
4赵军,吴庆周,刘全良,等.唐山地区10210例成人空腹血脂水平分析[J].华北煤炭医学院学报,2008,10(5):587-589.
5胡声迪,郭金枝,马曦.大豆β-伴大豆球蛋白研究进展[J].中国畜牧杂志,2010,46(5):65-68.
6 OHARA S,MATSUI Y,MAKOTO T,et al.Serum triacylglycerol-lowering effect of soybean-conglycinin in mildly hypertriacylglycerolemic individuals[J].Clin Nutr Metab,2007,2:12-16.
7 ROSSOUW J E.Hormones,genetic factors,and gender differences in cardiovascular disease[J].Cardiovasc Res,2002,53(3):550-557.
8中华人民共和国卫生部.保健食品检验与评价技术规范[M].北京:卫生部,2003:35-38.
9 SETSU O,YASUNORI M,MAKOTO T,et al.Serum triacylglycerol-lowering effect of soybeanβ-conglycinin in mildly hypertriacylglycerolemic individuals e-SPEN[J].Eur J Clin Nutr Metab,2007,2(1):12-16.
10 FERREIRA E S,SILVA M A,DEMONTE A,et al.Beta-conglycinin combined with fenofibrate or rosuvastatin have exerted distinct hypocholesterolemic effects in rats[J].Lipids Health Dis,2012,11(1):11.
11 FUKUI K,KOJIMA M,TSCHIBANA N,et al.Effects of soybean beta-conglycinin on hepatic lipid metabolism and fecal lipid excretion in normal adult rats[J].Biosci Biotechnol Biochem,2004,68(5):1153-1155.
12 MORIYAMA T,KISHIMOTO K,NAGAI K,et al.Soybean beta-conglycinin diet suppresses serum triglyceride levels in normal and genetically obese mice by induction of beta-oxidation,downregulation of fatty acid synthase,and inhibition of triglyceride absorption[J].Biosci Biotechnol Biochem,2004,68(2):352-359.
13 TACHIBANA N,IWAOKA Y,HIROTSUKA M,et al.Beta-conglycinin lowers very-low-density lipoprotein-triglyceride levels by increasing adiponectin and insulin sensitivity in rats[J].Biosci Biotechnol Biochem,2010,74(6):1250-1255.
14 BABA T,UEDA A,KOHNO M,et al.Effects of soybean beta-conglycinin on body fat ratio and serum lipid levels in healthy volunteers of female university students[J].J Nutr Sci Vitaminol(Tokyo),2004,50(1):26-31.
15邵永强.温州市人群血脂水平及血脂异常率流行特征调查[J].现代预防医学杂志,2011,23(1):22-58.
基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2012.04.018
中图分类号:R589.2
引用信息:
[1]贾梦,卓兴钢,韩方群,等.大豆β-伴球蛋白对40～60岁高脂血症妇女血清甘油三酯的降低作用[J].卫生研究,2012,41(04):594-597.DOI:10.19813/j.cnki.weishengyanjiu.2012.04.018.
基金信息:
北京大学公共卫生学院与日本国立健康·营养研究所合作项目
2012-07-30
2012-07-30