卫生研究

为建立更合理而实用的高脂血症动物模型 ,比较了SD大鼠、Wistar大鼠和金黄地鼠的血清和肝脏脂质对高脂饲料的反应。大鼠高脂饲料配方为 1%胆固醇、10 %猪油、10 %蛋黄粉和 79%基础饲料 ;金黄地鼠高脂饲料配方为 0 2 %胆固醇、15 %猪油和 85 %基础饲料。结果显示 ,经过高脂饲料喂养 5周后 ,SD大鼠、Wistar大鼠和金黄地鼠高脂组血清甘油三酯水平分别比对照组高 194 4 %、86 2 %和 84 3 % (P <0 0 5 ) ,血清总胆固醇水平分别比对照组高 76 8%、4 8 3 %和 13 4 8% (P <0 0 5 )。提示金黄地鼠是一种良好的高胆固醇血症模型 ,而SD大鼠可能是一种较好的高甘油三酯血症模型。

To establish a better animal model for hyperlipidemia, three animal models with SD rats, Wistar rats and golden hamsters were explored. The semi purified diet for rats was composed of 1% cholesterol, 10% lard, 10% yolk powder and 79% normal diet. The semi purified diet for hamster was composed of 0.2% cholesterol, 15% lard and 85% normal diet. Serum TC, TG, HDL C, liver cholesterol and triglyceride were assayed. Serum TG of SD rat, Wistar rat and hamster was 194 4%, 86 2% and 84 3% respectively higher than that of control after 5 weeks of experiment. Serum TC of the three groups was 76 8%, 48 3% and 134 8% respectively higher than that of control. The results suggested that hamster might be a better animal model for hypercholesterolemia and SD rat might be better for hypertriglyceridemia.