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目的了解菰米的血糖生成指数(GI),观察菰米对高脂饲料诱导的胰岛素抵抗(IR)大鼠的作用。方法以50 g葡萄糖为对照,测定健康成人(n=8)食用67 g菰米后2 h内的血糖水平,并根据Wolver方法计算菰米GI。50只雄性SD大鼠随机分成阴性对照组、IR模型组、高剂量菰米组、低剂量菰米组和米面组,喂养8周,测定大鼠空腹血糖(FPG)、空腹胰岛素(INS)、糖化血红蛋白(Hb A1c)和胰高血糖素(GC),计算胰岛素抵抗指数(HOMA-IR)。结果菰米的GI为53.72。IR模型组和米面组大鼠体重、FPG、INS、GC水平和HOMA-IR均高于阴性对照组(P<0.05);与IR模型组和米面组相比,高剂量菰米组和低剂量菰米组大鼠体重降低,FPG、INS、GC水平和HOMA-IR均显著下降(P<0.05);低剂量菰米组大鼠血清FPG、INS、GC水平略高于阴性对照组和高剂量菰米组,但差异无统计学意义。结论菰米属于低血糖生成指数食物,同时菰米能改善高脂饲料诱导的大鼠胰岛素抵抗,用菰米替代50%的精米面能改善大鼠的胰岛素抵抗状态。
Abstract：Objective To investigate the glycemic index( GI) of wild rice,and observe the effects of wild rice on the insulin resistance( IR) rats induced by high fat diet. Methods With 50 g glucose as control,measured healthy adults( n = 8) blood glucose levels after eating 67 g wild rice within 2 h,and using Jenkins and Wolever formula to calculate the GI. 50 male SD rats were randomly divided into negative control group,IR model group,high-dose of wild rice group,low-dose of wild rice group and white rice-flour group,continuous feeding eight weeks. Fasting blood glucose( FPG),fasting insulin( INS),glycosylated hemoglobin( Hb A1c) and glucagon( GC) were measured,and insulin resistance index( HOMA-IR) was calculated. Results The GI of wild rice was 53. 72. Compared with the negative control group,the rats of IR model group and white rice-flour group had higher body weight,FPG,INS,GC levels and HOMA-IR( P < 0. 05). Compared with the white rice-flour and IR model group,FPG,INS,GC levels and HOMA-IR in rats fed high-dose of wild rice and low-dose of wild ricediet were significantly decreased( P < 0. 05). The rats fed with low-dose of wild rice diet had slightly increased FPG,INS,GC levels and HOMA-IR,but the difference was not statistically significant. Conclusion Wild rice is a low glycemic index food,while wild rice can improve the resistance in rats induced by high fat diet,and replace 50% of the refined rice and flour with wild rice can improve insulin resistance in rats.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2015.02.001
中图分类号:R965
引用信息:
[1]张红,刘洋,赵军红,等.菰米血糖生成指数的测定及其改善大鼠胰岛素抵抗的作用[J].卫生研究,2015,44(02):173-178+184.DOI:10.19813/j.cnki.weishengyanjiu.2015.02.001.
基金信息:
国家自然科学基金(No.81202195,81372986); 教育部博士点基金(No.20120092120063)
2015-03-30
2015-03-30