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目的 了解北京体育大学新生高尿酸血症患病情况，探讨大学生人群高尿酸血症的相关因素。方法 于2021年9月—2022年2月选取北京体育大学3372名新生作为研究对象，进行非同日的2次血尿酸检测，计算人群患病率并使用病例-对照的方法探讨大学生群体高尿酸血症危险因素，以方便抽样的方法从该人群的高尿酸血症患者中抽取246人纳入病例组，从非高尿酸血症者中如抽取211人纳入对照组，进行体格检查和实验室检查，并进行回顾性的问卷调查，包括年龄、性别、专业、生源地等一般情况和高尿酸血症相关饮食、高尿酸血症疾病认知、体力活动水平、睡眠情况等内容。采用卡方分析、单因素Logistic回归分析及多因素Logistic回归分析进行统计分析。结果 非同日2次血尿酸检测实际确诊高尿酸血症患者人数为479人(14.21%);其中男性391人(22.39%),女性88人(5.41%)。病例-对照研究共纳入457名研究对象，其中病例组246人(男性218人，女性28人，年龄19.74岁),对照组211人(男性177人，女性34人，年龄19.93岁),2组受试者在性别和年龄分布上差异无统计学意义。单因素Logistic回归分析结果表明中心性肥胖(OR=31.52,95%CI 7.59～130.86)、肥胖(OR=2.59,95%CI 1.20～5.58)、超重(OR=1.67,95%CI 1.08～2.59)、经常食用新鲜蔬菜(OR=0.66,95%CI 0.43～0.99)以及每日饮水1500～2000 mL(OR=0.63,95%CI 0.41～0.95)与高尿酸血症有关；将以上因素进行多因素Logistic回归分析，最终中心性肥胖(OR=32.05,95%CI 7.65～134.20)、肥胖(OR=3.22,95%CI 1.44～7.20)以及每日饮水1500～2000 mL(OR=0.60,95%CI 0.37～0.95)在P=0.05的水平上被模型纳入。结论 该大学新生高尿酸血症患病率较高，其中男性患病情况更普遍。肥胖以及中心性肥胖是大学生群体高尿酸血症的危险因素，每日饮水量1500～2000 mL是保护因素。
Abstract：OBJECTIVE To investigate the prevalence of hyperuricemia among freshmen enrolled in Beijing Sport University and to explore the influencing factors of hyperuricemia in the college population.METHODS The study period was from September 2021 to February 2022.3372 freshmen of the class of 2021 from Beijing Sport University in Beijing were selected as the study subjects, and two blood uric acid tests were performed on non-same days to calculate the prevalence of the population and to explore the risk factors of hyperuricemia in the college student population using a case-control method. 246 people were selected from the hyperuricemia patients of the population to be included in the case group by convenience sampling, and 211 people were selected from the non-hyperuricemia persons of the population to be included in the control group. They were included in the control group, underwent physical and laboratory examinations, and were retrospectively surveyed with questionnaires that included general information such as age, gender, specialty, place of birth, and diet related to hyperuricemia, awareness of hyperuricemia disease, physical activity level, and sleep. Statistical analysis was performed using chi-square analysis, one-way Logistic regression analysis, and multi-factor logistic regression analysis. RESULTS The number of patients actually diagnosed with hyperuricemia by two blood uric acid tests on non-same days was 479, with a population prevalence rate of 14.21%. Among them, the number of males in the diseased population was 391(22.39%), and the number of females in the diseased population was 88(5.41%). A total of 457 subjects were enrolled in the case-control study, among them, 246 in the case group(218 males and 28 females, average age 19.74 years), 211 in the control group(177 males and 34 females, average age 19.93 years), and 247 in the case group, 211 in the control group, and 2 groups of subjects were included. A total of 211 subjects, and there was no significant difference between the 2 groups in terms of gender composition and age distribution. One-way logistic regression analysis showed that central obesity(OR=31.52, 95%CI 7.59-130.86), obesity(OR=2.59, 95%CI 1.20-5.58), overweight(OR=1.67, 95%CI 1.08-2.59), frequent consumption of fresh vegetables(OR=0.66, 95%CI 0.43-0.99), and drinking 1500-2000 mL of water per day(OR=0.63, 95%CI 0.41-0.95) were associated with hyperuricemia, and multifactorial Logistic regression analyses were performed to analyze the above factors, and finally central obesity(OR=32.05, 95%CI 7.65-134.20), BMI obesity(OR=3.22, 95%CI 1.44-7.20), and daily water intake of 1500-2000 mL(OR=0.60, 95%CI 0.37-0.95) were included in the model at the level of P=0.05.CONCLUSION The current high prevalence of hyperuricemia in the college student population, which is more prevalent in male college students. Obesity and central obesity are risk factors for hyperuricemia in young college students, and daily water intake of 1500-2000 mL is a protective factor.
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基本信息:
DOI：10.19813/j.cnki.weishengyanjiu.2024.04.011
中图分类号:R589.7
引用信息:
[1]于文朗,王雯星,赵元慧,等.2021—2022年北京体育大学新生高尿酸血症患病情况及相关因素[J].卫生研究,2024,53(04):592-599+607.DOI:10.19813/j.cnki.weishengyanjiu.2024.04.011.
基金信息:
国家重点研发计划(No.2018YFC2000604)
2024-07-25
2024-07-25