卫生研究

参考文献

1 JAENISCH R,MINTZ B.Simian virus 40 DNA sequences inDNA of healthy adult mice derived from preimplantationblastocysts injected with viral DNA[J].Proc Natl Acad Sci U SA,1974,71:1250-1254.

2 JAENISCH R.Germ line integration and Mendelian transmissionof the exogenous Moloney leukemia virus[J].Proc Natl Acad SciUSA,1976,73:1260-1264.

3 GORDON J W,SCANGOS G A,PLOTKIN D J,et al.Genetictransformation of mouse embryos by microin-jection of purifiedDNA[J].Proc Natl Acad Sci USA,1980,77:7380-7384.

4 GAMA SOSA M A,DE GASPERI R,ELDER G A.Animaltransgenesis:an overview[J].Brain Struct Funct,2010,214:91-109.

5 YOKOHIRA M,ARNOLD L L,PENNINGTON K L,et al.Severesystemic toxicity and urinary bladder cytoto-xicity andregenerative hyperplasia induced by arsenite in arsenic(+3oxidation state)methyltransferase knoc-kout mice.A preliminaryreport[J].Toxicol Appl Pharmacol,2010,246:1-7.

6 HUGHES M F,EDWARDS B C,HERBIN-DAVIS K M,et al.Arsenic(+3 oxidation state)methyltransferase genotype affectssteady-state distribution and clearance of arsenic in arsenate-treated mice[J].Toxicol Appl Pharmacol,2010,249:217-223.

7 DROBNA Z,NARANMANDURA H,KUBACHKA K M,et al.Disruption of the arsenic(+3 oxidation state)methyltransferasegene in the mouse alters the phenotype for methylation of arsenicand affects distribution and retention of orally administeredarsenate[J].Chem Res Toxicol,2009,22:1713-1720.

8 YOKOHIRA M,ARNOLD L L,PENNINGTON K L,et al.Effectof sodium arsenite dose administered in the drinking water on theurinary bladder epithelium of female arsenic(+3 oxidationstate)methyltransferase knockout mice[J].Toxicol Sci,2011,121:257-266.

9 MUNIZ ORTIZ J G,SHANG Junjun,CATRON B,et al.Atransgenic Drosophila model for arsenic methylation suggests ametabolic rationale for differential dose-dependent toxicityendpoints[J].Toxicol Sci,2011,121:303-311.

10 FLAVENY C A,PERDEW G H.Transgenic humanized AHRmouse reveals differences between human and mouse AHR ligandselectivity[J].Mol Cell Pharmacol,2009,1:119-123.

11 MORIGUCHI T,MOTOHASHI H,HOSOYA T,et al.Distinctresponse to dioxin in an arylhydrocarbon recep-tor(AHR)-humanized mouse[J].Proc Natl Acad Sci USA,2003,100:5652-5657.

12 FLAVENY C A,MURRAY I A,CHIARO C R,et al.Ligandselectivity and gene regulation by the human aryl hydrocarbonreceptor in transgenic mice[J].Mol Pharmacol,2009,75:1412-1420.

13 LOHMAN P H,VIJG J,UITTERLINDEN A G,et al.DNAmethods for detecting and analyzing mutations in vivo[J].MutatRes,1987,181:227-234.

14 BOVERHOF D R,CHAMBERLAIN M P,ELCOMBE C R,et al.Transgenic animal models in toxicology:histo-rical perspectivesand future outlook[J].Toxicol Sci,2011,121:207-233.

15 GOSSEN J A,DE LEEUW W J,TAN C H,et al.Effi-cient rescueof integrated shuttle vectors from transgenic mice:a model forstudying mutations in vivo[J].Proc Natl Acad Sci USA,1989,86:7971-7975.

16 GOSSEN J A,MARTUS H J,WEI J Y,et al.Sponta-neous andX-ray-induced deletion mutations in a LacZ plasmid-basedtransgenic mouse model[J].Mutat Res,1995,331:89-97.

17 NOHMI T,KATOH M,SUZUKI H,et al.A new transgenic mousemutagenesis test system using Spi-and 6-thioguanine selections[J].Environ Mol Mutagen,1996,28:465-470.

18 VALENTINE C R,RAINEY H F,FARRELL J M,et al.Frequency and spectrum of ENU-induced mutation in the PhiX174 transgene in mouse splenic lymphocytes and theirsignificance to spontaneous transgenic rodent mutationfrequencies[J].Mutagenesis,2008,23:383-397.

19 TOYODA-HOKAIWADO N,INOUE T,MASUMURA K,et al.Integration of in vivo genotoxicity and short-term carcinogenicityassays using F344 gpt delta transgenic rats:in vivo mutagenicityof 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers[J].Toxicol Sci,2010,114:71-78.

20 DOBROVOLSKY V N,MIURA D,HEFLICH R H,et al.The invivo Pig-a gene mutation assay,a potential tool for regulatorysafety assessment[J].Environ Mol Muta-gen,2010,51:825-835.

21曹洁,印木泉.基于质粒的转基因小鼠致突变检测模型的研究进展[J].中国公共卫生,2000,16(6):570-571.

22 LAMBERT I B,SINGER T M,BOUCHER S E,et al.Detailedreview of transgenic rodent mutation assays[J].Mutat Res,2005,590:1-280.

23 HUMBLE M C,TREMPUS C S,SPALDING J W,et al.Biological,cellular,and molecular characteristics of an inducibletransgenic skin tumor model:a review[J].Oncogene,2005,24:8217-8228.

24 GERSON S L,ZAIDI N H,DUMENCO L L,et al.Alkyltransferase transgenic mice:probes of chemicalcarcinogenesis[J].Mutat Res,1994,307:541-555.

25 DONEHOWER L A,LOZANO G.20 years studying p53 functionsin genetically engineered mice[J].Nat Rev Cancer,2009,9:831-841.

26 ROBINSON D E,MACDONALD J S.Background and frameworkfor ILSI's collaborative evaluation program on alternative modelsfor carcinogenicity assessment.International Life SciencesInstitute[J].Toxicol Pathol,2001,29(Suppl):13-19.

27 BUTERS J,QUINTANILLA-MARTINEZ L,SCHOBER W,et al.CYP1B1 determines susceptibility to low doses of 7,12-dimethylbenz[a]anthracene-induced ovarian cancers in mice:correlation of CYP1B1-mediated DNA adducts with carcinoge-nicity[J].Carcinogenesis,2003,24:327-334.

28 ABDELMEGEED M A,MOON K H,CHEN Chi,et al.Role ofcytochrome P450 2E1 in protein nitration and ubiquitin-mediateddegradation during acetaminophen toxicity[J].BiochemPharmacol,2010,79:57-66.

29 UNO S,DALTON T P,DERKENNE S,et al.Oral exposure tobenzo[a]pyrene in the mouse:detoxication by induciblecytochrome P450 is more important than metabolic activation[J].Mol Pharmacol,2004,65:1225-1237.

30 YOSHIDA M,WATANABE C,KISHIMOTO M,et al.Behavioralchanges in metallothionein-null mice after the cessation of long-term,low-level exposure to mercury vapor[J].Toxicol Lett,2006,161:210-218.

31 YOSHIDA M,SHIMIZU N,SUZUKI M,et al.Emergence ofdelayed methylmercury toxicity after perinatal exposure inmetallothionein-null and wild-type C57BL mice[J].EnvironHealth Perspect,2008,116:746-751.

32 YE B,RUI Q,WU Q,et al.Metallothioneins are required forformation of cross-adaptation response to neurobeha-vioral toxicityfrom lead and mercury exposure in nematodes[J].PLoS One,2010,5:e14052.

33 DOLGIN E.Mouse library set to be knockout[J].Nature,2011,474:262-263.