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在世界范围内,每年合成和生产的化学物质以惊人的数字增长,化学品污染可能对环境和人体造成潜在风险。基于传统的动物试验方法无法对数量庞大的化学物质逐一测试,且存在成本高、耗时长、种属外推不确定性等问题,因此无法满足风险评估和风险管理的需求。开发新方法填补化学物质的毒理学数据缺口迫在眉睫。在上述背景的推动下,非动物实验替代方法蓬勃开展,其中以计算毒理学技术为代表的新技术受到广泛关注。本文从计算毒理学的诞生和发展、研究方法、常用数据库、代表性软件及在化学物风险评估的应用等方面进行阐述,以期为我国化学物风险评估领域的进一步发展提供参考。
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基本信息:
DOI:10.19813/j.cnki.weishengyanjiu.2025.02.024
中图分类号:TQ086.51
引用信息:
[1]吴难,张磊.计算毒理学技术在化学物风险评估中的应用[J].卫生研究,2025,54(02):332-341+348.DOI:10.19813/j.cnki.weishengyanjiu.2025.02.024.
基金信息:
国家食品安全风险评估中心高层次人才队伍建设项目
2024-09-13
2024
2024-12-05
2024-12-13
2024
1
2025-03-13
2025-03-13