卫生研究

参考文献

[1]LUEBKE R.Immunotoxicity screening and prioritization in the twenty-first century[J].Toxicol Pathol,2012,40(2):294-299.

[2]ICH.Guidance for industry:S8 immunotoxicitystudies for human pharmaceuticals[S].International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use,2006.

[3]Regulation(EC)No 1907/2006 of The European Parliament and of The Council of 18 December 2006:Concerning the Registration,Evaluation,Authorisation and Restriction of Chemicals(REACH),establishing a European Chemicals Agency,amending Directive 1999/45/EC and repealing Council Regulation(EEC)No 793/93 and Commission Regulation(EC)No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives91/155/EEC,93/67/EEC,93/105/EC and 2000/21/EC[S].Official Journal of the European Union,2006.

[4]GENNARI A,BAN M,BRAUN A,et al.The use of in vitro systems for evaluating immunotoxicity:The report and recommendations of an ECVAM workshop[J].J Immunotoxicol,2005,2:61-83.

[5]VAN DER LAAN J W,VAN LOVEREN H.Current status and burning issues in immunotoxicity testing of drugs[J].Toxicol Appl Pharm,2005,207:S435-S440.

[6]CARFI M,GENNARI A,MALERBA I,et al.In vitro tests to evaluate immunotoxicity:a preliminary study[J].Toxicology,2007,229:11-22.

[7]DURAMAD P,HOLLAND N T.Biomarkers of immunotoxicity for environmental and public health research[J].Int J Environ Res Public Health,2011,8:1388-1401.

[8]ULLERAS E,TRZASKA D,ARKUSZ J,et al.Development of the“Cell Chip”:a new in vitro alternative technique for immunotoxicity testing[J].Toxicology,2005,206:245-256.

[9]BURNS-NAAS L A,KERKVLIET N I,LASKIN D L,et al.The use of multiparameter flow cytometry in immunotoxicology and immunopharmacology[M]//LUEBKE R W,HOUSE R,KIMBER I,Eds.Immunotoxicology and Immunopharmacology.3rd ed.Boca Raton:CRC Press,2007:97-122.

[10]TOMAR N,DE R K.Immunoinformatics:An integrated scenario[J].Immunology,2010,131:153-168.

[11]STEINER G,SUTER L,BOESS F,et al.Discriminating different classes of toxicants by transcript profiling[J].Environ Health Perspect,2004,112:1236-1248.

[12]LUEBKE R W,HOLSAPPLE M P,LADICS G S,et al.Immunotoxicogenomics:the potential of genomics technology in the immunotoxicity risk assessmentprocess[J].Toxicol Sci,2006,94(1):22-27.

[13]DIAZ-RAMOS M C,ENGEL P,BASTOS R.Towards a comprehensive human cell-surface immunome database[J].Immunol Lett,2010,134:183-187.

[14]CORSINI E,ROGGEN E L.Opportunities for nonanimal test development[J].Alternatives to Laboratory Animals(ATLA),2009,37:387-397.

[15]LYONS A B,PARIS C R.Determination of lymphocyte division by flow cytometry[J].J Immunol Methods,l994,171(1):131-137.

[16]THOMPSON B S,MITCHELL T C.Measurement of daughter cell accumulation during lymphocyte proliferation in vivo[J].J Immunol Methods,2004,295:79-87.

[17]MARCUSSON-STAHL M,CEDERBRANT K.A flow-cytometric NK-cytotoxicity assay adapted for use in rat repeated dose toxicity studies[J].Toxicology,2003,193:269-279.

[18]CHOLUJOVD,JAKUBKOVJ,KUBES M,et al.Comparative study of four fluorescent probes for evaluation of natural killer cell cytotoxicity assays[J].Immunobiology,2008,213:629-640.

[19]LECOEUR H,FEVRIER M,GARCIA S,et al.A novel flow cytometric assay for quantitation and multiparametric characterization of cell-mediated cytotoxicity[J].J Immunol Methods,2001,253:177-187.

[20]BURNS-NAAS L A,HASTINGS K L,LADICS G S,et al.What's so special about the developing immunesystem?[J].Int J Toxicol,2008,27:223-54.

[21]DEWITT J C,PEDEN-ADMS M M,KEIL D E,et al.Current status of developmental immunotoxicity:early-life patterns and testing[J].Toxicol Pathol,201,39:1-7.

[22]DIETERT R R,LEE J E,HUSSAIN I,et al.Developmental immunotoxicity of lead[J].Toxicol Appl Pharmacol,2004,198:86-94.

[23]WEINSTOCK D,LEWIS D B,PARKER G A,et al.Toxicopathology of the developing immune system:Investigative and development strategies[J].Toxicol Pathol,2010,38:1111-1117.

[24]DIETERT R R,DIETERT J M.Potential for earlylife immune insult including developmental immunotoxicity in autism and autism spectrum disorders:Focus on critical windows of immune vulnerability[J].J Toxicol Environ Health B Crit Rev,2008,11:660-680.

[25]LUEBKE R W,CHEN D H,DIETERT R,et al.The comparative immunotoxicity of five selected compounds following developmental or adult exposure[J].J Toxicol Environ Health B Crit Rev,2006,9:1-26.

[26]EPA OPPTS 870.7800,Health effects test guidelines:Immunotoxicity[S].Washington DC:United States Environmental Protection Agency,Office of Prevention,Pesticides and Toxic Substances,2007.